Dhaarani Jayaraman , Harshavardhan Mahalingam , Naga Geetha Rani Mangam , Swati Narasimhan , Padmasani Venkat Ramanan , K. Stephen Sudhakar , Prasanna Kumar S , Banu Keerthana , Manu Vidhya Harikumar , Anupama Jyoti Kindo , T.K. Shruthi , Niranjan Ragavan , Julius Xavier Scott
{"title":"Mucor thriving on iron in beta thalassemia major: A case of rhino-orbital mucormycosis","authors":"Dhaarani Jayaraman , Harshavardhan Mahalingam , Naga Geetha Rani Mangam , Swati Narasimhan , Padmasani Venkat Ramanan , K. Stephen Sudhakar , Prasanna Kumar S , Banu Keerthana , Manu Vidhya Harikumar , Anupama Jyoti Kindo , T.K. Shruthi , Niranjan Ragavan , Julius Xavier Scott","doi":"10.1016/j.phoj.2024.09.003","DOIUrl":null,"url":null,"abstract":"<div><p>Mucormycosis is a dreaded condition with high mortality rates noted in immunocompromised hosts. Though iron overload is a known risk factor, children with transfusion-dependent thalassemia have been rarely reported with invasive mucormycosis. We present an 8-year-old girl with transfusion-dependent thalassemia with hypersplenism and iron overload. She had invasive rhino-sino-orbital mucormycosis with a fatal outcome despite aggressive surgical and medical management.</p></div>","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 4","pages":"Pages 271-273"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468124524000743/pdfft?md5=730979c1a3f034f0f6573ada92f56611&pid=1-s2.0-S2468124524000743-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Hematology Oncology Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468124524000743","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Mucormycosis is a dreaded condition with high mortality rates noted in immunocompromised hosts. Though iron overload is a known risk factor, children with transfusion-dependent thalassemia have been rarely reported with invasive mucormycosis. We present an 8-year-old girl with transfusion-dependent thalassemia with hypersplenism and iron overload. She had invasive rhino-sino-orbital mucormycosis with a fatal outcome despite aggressive surgical and medical management.
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