Gaps in evidence in the treatment of prevalent patients with pulmonary arterial hypertension at intermediate risk: An expert consensus

IF 3.5 3区 医学 Q2 PHARMACOLOGY & PHARMACY
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引用次数: 0

Abstract

Despite the innovations introduced in the 2022 European Society of Cardiology/European Respiratory Society Guidelines on Pulmonary Hypertension, risk discrimination and management of pulmonary arterial hypertension (PAH) patients at intermediate risk still represents a grey zone. Additionally, clinical evidence derived from currently available studies is limited. This expert panel survey intends to aid physicians in choosing the best therapeutic strategy for patients at intermediate risk despite ongoing oral therapy. An expert panel of 24 physicians, specialized in cardiology and/or pulmonology with expertise in handling all drugs available for the treatment of PAH participated in the survey. All potential therapeutic options for patients at intermediate risk were explored and analyzed to produce graded consensus statements regarding: the switch from endothelin receptor antagonist (ERA) or phosphodiesterase 5 inhibitor (PDE5i) to another oral drug of the same class; the addition of a drug targeting the prostacyclin pathway administered by different routes; the switch from PDE5i to riociguat.

Abstract Image

治疗中危肺动脉高压患者的证据差距:专家共识
尽管 2022 年欧洲心脏病学会/欧洲呼吸学会肺动脉高压指南进行了创新,但中危肺动脉高压(PAH)患者的风险识别和管理仍然是一个灰色地带。此外,从现有研究中获得的临床证据也很有限。这项专家小组调查旨在帮助医生为正在接受口服治疗的中危患者选择最佳治疗策略。由 24 名心脏病学和/或肺病学专科医生组成的专家小组参与了此次调查,他们都具有处理所有可用于治疗 PAH 的药物的专业知识。他们对中危患者的所有潜在治疗方案进行了探讨和分析,并就以下方面达成了分级共识声明:从内皮素受体拮抗剂(ERA)或磷酸二酯酶 5 抑制剂(PDE5i)换成另一种同类口服药物;通过不同途径添加一种靶向前列环素途径的药物;从 PDE5i 换成利奥吉曲特。
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来源期刊
Vascular pharmacology
Vascular pharmacology 医学-药学
CiteScore
6.60
自引率
2.50%
发文量
153
审稿时长
31 days
期刊介绍: Vascular Pharmacology publishes papers, which contains results of all aspects of biology and pharmacology of the vascular system. Papers are encouraged in basic, translational and clinical aspects of Vascular Biology and Pharmacology, utilizing approaches ranging from molecular biology to integrative physiology. All papers are in English. The Journal publishes review articles which include vascular aspects of thrombosis, inflammation, cell signalling, atherosclerosis, and lipid metabolism.
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