{"title":"Inflammatory mechanisms as a potential cause of sciatica in lumbar disc herniation: A hypothesis","authors":"Lei Zhou, Yong Tang, Jihong Jiang, Yangsheng Wang, Changwei Chen, Feng Zhu","doi":"10.1016/j.mehy.2024.111485","DOIUrl":null,"url":null,"abstract":"<div><p>Lumbar disc herniation frequently causes low back pain and sciatica, significantly impacting patients’ quality of life. The pathogenesis of sciatica is complex, involving both mechanical compression and inflammatory processes. Recent studies have suggested a potential role of inflammatory mechanisms in the development of sciatica. We hypothesize that these inflammatory mediators contribute to the neuropathic pain experienced by patients with lumbar disc herniation. Understanding these inflammatory mechanisms may lead to novel therapeutic targets for managing sciatica in lumbar disc herniation, ultimately improving patient outcomes. Future research should focus on testing this hypothesis through scientific investigation to validate these potential new therapies.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"192 ","pages":"Article 111485"},"PeriodicalIF":2.1000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0306987724002287/pdfft?md5=2a5b1e970a34f61fe6e655e9a0259a27&pid=1-s2.0-S0306987724002287-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724002287","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Lumbar disc herniation frequently causes low back pain and sciatica, significantly impacting patients’ quality of life. The pathogenesis of sciatica is complex, involving both mechanical compression and inflammatory processes. Recent studies have suggested a potential role of inflammatory mechanisms in the development of sciatica. We hypothesize that these inflammatory mediators contribute to the neuropathic pain experienced by patients with lumbar disc herniation. Understanding these inflammatory mechanisms may lead to novel therapeutic targets for managing sciatica in lumbar disc herniation, ultimately improving patient outcomes. Future research should focus on testing this hypothesis through scientific investigation to validate these potential new therapies.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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