Milk intake, lactase non-persistence and type 2 diabetes risk in Chinese adults

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-09-18 DOI:10.1038/s42255-024-01128-2

Maria G. Kakkoura, Robin G. Walters, Robert Clarke, Zhengming Chen, Huaidong Du

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引用次数: 0

Abstract

arising from K. Luo et al. Nature Metabolism https://doi.org/10.1038/s42255-023-00961-1 (2024)

In the 2024 January issue of Nature Metabolism, Luo et al.¹ reported an inverse association between milk intake and risk of type 2 diabetes (T2D) among individuals who were lactase non-persistent (LNP), as determined by the lactase (LCT) rs4988235 homozygous GG genotype. The authors also reported inverse cross-sectional associations of milk intake with several T2D-related metabolic traits, including body mass index (BMI) and waist circumference (WC) in LNP individuals. However, in their analyses, no adjustments for BMI/WC were done in assessing the association between milk intake and T2D risk, which may lead to biased results. Given the established causal relevance of adiposity for incident T2D^2,3 and the observed inverse associations of milk intake with adiposity in the study population, it is therefore important to establish whether the associations of milk consumption, milk-associated gut bacteria and milk-associated metabolites with T2D risk are confounded, or mediated, by BMI/WC in the paper by Luo et al.

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中国成年人的牛奶摄入量、乳糖不耐受性与 2 型糖尿病风险

来源于 K. Luo 等人的文章。Nature Metabolism https://doi.org/10.1038/s42255-023-00961-1 (2024)在 2024 年 1 月出版的《Nature Metabolism》杂志上，Luo 等人1 报道了牛奶摄入量与乳糖酶非持久性（LNP）个体（由乳糖酶（LCT）rs4988235 同源 GG 基因型确定）的 2 型糖尿病（T2D）风险之间的反比关系。作者还报告了牛奶摄入量与几种与 T2D 相关的代谢特征（包括 LNP 人群的体重指数 (BMI) 和腰围 (WC)）的横断面逆相关性。然而，在他们的分析中，在评估牛奶摄入量与 T2D 风险之间的关系时，没有对体重指数/腰围进行调整，这可能会导致结果偏差。鉴于已确定肥胖与 T2D 发病的因果关系2,3 ，以及在研究人群中观察到的牛奶摄入量与肥胖的反向关系，因此，确定牛奶摄入量、牛奶相关肠道细菌和牛奶相关代谢物与 T2D 风险的关系是否受 BMI/WC 的干扰或介导，在 Luo 等人的论文中非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.