Nickel(II) complex anchoring on anatase nanoparticles: A multifunctional approach to anticancer, anti-inflammatory, and antioxidant activities

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-09-11 DOI:10.1016/j.molstruc.2024.140034

{"title":"Nickel(II) complex anchoring on anatase nanoparticles: A multifunctional approach to anticancer, anti-inflammatory, and antioxidant activities","authors":"","doi":"10.1016/j.molstruc.2024.140034","DOIUrl":null,"url":null,"abstract":"<div>In this study, a biologically active nickel(II) complex, [Ni(bipy)3]Cl2 (where bipy = 2,2′-bipyridine), was synthesized using a straightforward precipitation method. This nickel(II) complex was subsequently grafted onto anatase (TiO2) nanoparticles (NPs) through an adsorption technique, yielding nickel(II)-complex-grafted anatase (Ni-TiO2) NPs. The Ni-TiO2 NPs were thoroughly characterized using a range of analytical methods, including X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, UV–visible spectroscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDAX), which confirmed the successful grafting of the complex onto the TiO2 NPs and maintained the structural integrity of the composite. The anticancer activity of the Ni-TiO2 NPs was assessed on Non-Small Cell Lung Cancer (NSCLC) cell lines using the MTT assay, revealing a significant enhancement in anticancer efficacy, with a 69 % improvement in cell inhibition compared to untreated cells. Moreover, the antioxidant potential of the Ni-TiO2 NPs was evaluated using the 1-Diphenyl-2-picrylhydrazyl (DPPH) assay, and their anti-inflammatory activity was determined through the protein denaturation assay. Both assays demonstrated that the Ni-TiO2 NPs exhibited superior inhibitory effects compared to the precursor Ni(II) complex, indicating enhanced bioactivity.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286024025432","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

In this study, a biologically active nickel(II) complex, [Ni(bipy)₃]Cl₂ (where bipy = 2,2′-bipyridine), was synthesized using a straightforward precipitation method. This nickel(II) complex was subsequently grafted onto anatase (TiO₂) nanoparticles (NPs) through an adsorption technique, yielding nickel(II)-complex-grafted anatase (Ni-TiO₂) NPs. The Ni-TiO₂ NPs were thoroughly characterized using a range of analytical methods, including X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, UV–visible spectroscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDAX), which confirmed the successful grafting of the complex onto the TiO₂ NPs and maintained the structural integrity of the composite. The anticancer activity of the Ni-TiO₂ NPs was assessed on Non-Small Cell Lung Cancer (NSCLC) cell lines using the MTT assay, revealing a significant enhancement in anticancer efficacy, with a 69 % improvement in cell inhibition compared to untreated cells. Moreover, the antioxidant potential of the Ni-TiO₂ NPs was evaluated using the 1-Diphenyl-2-picrylhydrazyl (DPPH) assay, and their anti-inflammatory activity was determined through the protein denaturation assay. Both assays demonstrated that the Ni-TiO₂ NPs exhibited superior inhibitory effects compared to the precursor Ni(II) complex, indicating enhanced bioactivity.

Abstract Image

查看原文本刊更多论文

锚定在锐钛矿纳米粒子上的镍(II)复合物：抗癌、抗炎和抗氧化的多功能方法

本研究采用直接沉淀法合成了具有生物活性的镍(II)络合物[Ni(bipy)3]Cl2（其中 bipy = 2,2′-联吡啶）。随后，通过吸附技术将这种镍（II）络合物接枝到锐钛矿（TiO2）纳米粒子（NPs）上，得到镍（II）络合物接枝的锐钛矿（Ni-TiO2）NPs。利用一系列分析方法，包括 X 射线衍射 (XRD)、傅立叶变换红外光谱 (FT-IR)、紫外-可见光谱、扫描电子显微镜 (SEM) 和能量色散 X 射线光谱 (EDAX)，对 Ni-TiO2 NPs 进行了全面表征，证实了络合物成功接枝到 TiO2 NPs 上，并保持了复合材料结构的完整性。利用 MTT 法评估了 Ni-TiO2 NPs 在非小细胞肺癌（NSCLC）细胞系上的抗癌活性，结果显示抗癌效果显著增强，与未经处理的细胞相比，细胞抑制率提高了 69%。此外，还利用1-二苯基-2-苦基肼（DPPH）测定法评估了二氧化镍-二氧化钛纳米粒子的抗氧化潜力，并通过蛋白质变性测定法确定了其抗炎活性。这两项实验都表明，与前体 Ni（II）复合物相比，Ni-TiO2 NPs 表现出更优越的抑制效果，表明其生物活性更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.