From foes to friends; bacterial proteins for optimal wart cryotherapy

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-09-12 DOI:10.1016/j.mehy.2024.111480

Amir Mohammad Bagheri , Marzieh Sajadi Bami , Mana Khazaeli , Payam Khazaeli , Mandana Ohadi

引用次数: 0

Abstract

Warts are a common skin complaint caused by viral infections. Cryotherapy is a well-established approach for wart removal, which apply low temperatures to freeze and destroy infectious cells. However, this process may face-up several unwanted side effect on healthy nearby tissues. Besides, proper penetration of such temperature is also required to cause irreversible damages in deep-root infectious layers. In this respect, ice-producing proteins that are naturally found in some bacterial species, knowing as ice nucleation active (INA) bacteria, may be practical. In the current work, we hypothesized purification and encapsulation of these proteins into vesicular lipid particles (such as liposomes, niosomes, and exosomes) for an intralesional injection. Thereby, effective wart removal would be achieved even at low temperatures without undesirable effects.

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化敌为友；细菌蛋白质实现最佳疣冷冻疗法

疣是由病毒感染引起的一种常见皮肤病。冷冻疗法是一种行之有效的去疣方法，它利用低温冷冻和破坏感染细胞。然而，这一过程可能会对附近的健康组织产生一些不必要的副作用。此外，这种温度还需要适当渗透，才能对深根感染层造成不可逆的破坏。在这方面，某些细菌物种中天然存在的产冰蛋白质（即冰核活性细菌）可能是实用的。在目前的工作中，我们假设将这些蛋白质纯化并封装到囊状脂质颗粒（如脂质体、niosomes 和外泌体）中，然后进行穴内注射。这样，即使在低温条件下也能有效去除疣体，而不会产生不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.