A novel two-dimensional nickel-based complex regulate apoptosis in SKOV3 cells by enhancing reactive oxygen species generation

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-09-14 DOI:10.1016/j.molstruc.2024.140005

引用次数: 0

Abstract

Disrupting cancer cells' fragile redox balance is one of the most promising cancer therapy strategies. Ovarian malignant tumours, the most common gynecological malignant tumours, are difficult to treat. Therefore, the search for highly effective and low-toxicity drugs for ovarian cancer treatment has become an urgent challenge for scientists to break through. Based on the excellent bio-activity and anti-tumour properties of metal-organic complexes, a novel nickel-based complex with a 2D structure was synthesized in this paper. Based on the experimental results, it was found that the Ni complex up-regulated the intracellular oxidation level of ovarian cancer cells SKOV3 to generate more reactive oxygen species (ROS). This enhanced mitochondrial breakage and DNA damage, and ultimately led to ovarian tumour cell apoptosis.

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新型二维镍基复合物通过增强活性氧的生成调节 SKOV3 细胞凋亡

破坏癌细胞脆弱的氧化还原平衡是最有前途的癌症治疗策略之一。卵巢恶性肿瘤是最常见的妇科恶性肿瘤，治疗难度大。因此，寻找高效低毒的卵巢癌治疗药物已成为科学家亟待突破的难题。基于金属有机配合物优异的生物活性和抗肿瘤特性，本文合成了一种二维结构的新型镍基配合物。实验结果发现，镍络合物能提高卵巢癌细胞 SKOV3 的细胞内氧化水平，产生更多的活性氧（ROS）。这增强了线粒体断裂和 DNA 损伤，最终导致卵巢肿瘤细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.

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