D. Corrales , A. Santos-Lozano , S. López-Ortiz , A. Lucia , D. Ríos Insua
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引用次数: 0
Abstract
Background and Objective:
Only about 14% of eligible EU citizens finally participate in colorectal cancer (CRC) screening programs despite it being the third most common type of cancer worldwide. The development of CRC risk models can enable predictions to be embedded in decision-support tools facilitating CRC screening and treatment recommendations. This paper develops a predictive model that aids in characterizing CRC risk groups and assessing the influence of a variety of risk factors on the population.
Methods:
A CRC Bayesian Network is learnt by aggregating extensive expert knowledge and data from an observational study and making use of structure learning algorithms to model the relations between variables. The network is then parametrised to characterize these relations in terms of local probability distributions at each of the nodes. It is finally used to predict the risks of developing CRC together with the uncertainty around such predictions.
Results:
A graphical CRC risk mapping tool is developed from the model and used to segment the population into risk subgroups according to variables of interest. Furthermore, the network provides insights on the predictive influence of modifiable risk factors such as alcohol consumption and smoking, and medical conditions such as diabetes or hypertension linked to lifestyles that potentially have an impact on an increased risk of developing CRC.
Conclusion:
CRC is most commonly developed in older individuals. However, some modifiable behavioral factors seem to have a strong predictive influence on its potential risk of development. Modeling these effects facilitates identifying risk groups and targeting influential variables which are subsequently helpful in the design of screening and treatment programs.
期刊介绍:
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.