Short steps synthesis of unsymmetrical acetylenes from tetrachloroethylene and arylboronic acids using Suzuki coupling reaction and improvement of mild dechlorinations

Abstract

Short steps synthesis of unsymmetrical acetylenes from tetrachloroethylene and arylboronic acids, and the use of the metal Mg as the mild reagent for dechlorinations has been developed. Unsymmetrical acetylenes including the donor and acceptor diarylacetylenes were produced in good yields. The reaction optimization, scope and limitations, the scale-up reaction, and the evaluation of the step were studied for this paper.