N6-methyladenosine (m6A) RNA modification in fibrosis and collagen-related diseases

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-09-12 DOI:10.1186/s13148-024-01736-5

Man Tan, Siyi Liu, Lubin Liu

引用次数: 0

Abstract

Fibrosis is an abnormal tissue healing process characterized by the excessive accumulation of ECM components, such as COL I and COL III, in response to tissue injury or chronic inflammation. Recent advances in epitranscriptomics have underscored the importance of m6A modification in fibrosis. m6A, the most prevalent modification in eukaryotic RNA, is catalyzed by methyltransferases (e.g., METTL3), removed by demethylases (e.g., FTO), and recognized by reader proteins (e.g., YTHDF1/2). These modifications are crucial in regulating collagen metabolism and associated diseases. Understanding the role of m6A modification in fibrosis and other collagen-related conditions holds promise for developing targeted therapies. This review highlights the latest progress in this area.

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纤维化和胶原蛋白相关疾病中的 N6-甲基腺苷 (m6A) RNA 修饰

纤维化是一种异常的组织愈合过程，其特点是组织损伤或慢性炎症时 ECM 成分（如 COL I 和 COL III）的过度积累。m6A 是真核 RNA 中最常见的修饰，由甲氧基转移酶（如 METTL3）催化，由去甲基化酶（如 FTO）去除，并由阅读蛋白（如 YTHDF1/2）识别。这些修饰在调节胶原代谢和相关疾病方面至关重要。了解 m6A 修饰在纤维化和其他胶原蛋白相关疾病中的作用为开发靶向疗法带来了希望。本综述重点介绍了这一领域的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.