Film Ag/Au Heterostructures to Functionalize Implant Materials: Composition, Structure, Antibacterial Activity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-04 DOI:10.1134/S0022476624080055

S. I. Dorovskikh, E. S. Vikulova, T. Ya. Gusel’nikova, D. S. Sergeevichev, R. A. Shutilov, A. A. Zheravin, V. N. Ivanova, T. V. Basova, N. B. Morozova

{"title":"Film Ag/Au Heterostructures to Functionalize Implant Materials: Composition, Structure, Antibacterial Activity","authors":"S. I. Dorovskikh, E. S. Vikulova, T. Ya. Gusel’nikova, D. S. Sergeevichev, R. A. Shutilov, A. A. Zheravin, V. N. Ivanova, T. V. Basova, N. B. Morozova","doi":"10.1134/S0022476624080055","DOIUrl":null,"url":null,"abstract":"Film heterostructures of compositions Ag/Au/Ti and Ag/Au/CFR-PEEK are obtained by thermal evaporation with subsequent deposition of metallic gold sublayers and silver nanostructures on modern biomaterials (Ti-6Al-4V alloy, polyether ether ketone CFR-PEEK). Silver concentration is varied within 2.1-20.8 µg/cm2 by changing the initial metal portion (1.2-5 mg) and the number of successive depositions (1–3). According to SEM data, Ag nanofilms with a thickness up to 10-15 nm are formed on the surface of gold sublayers. According to XPS results, gold is present in the metallic state on the surface of biomaterials whereas along with metal, the Ag2O oxide phase is detected for silver. The dynamics of silver dissolution from the Ag/Au surface is analyzed by ICP-AES (2-48 h). It is found that regardless of the silver concentration, the samples demonstrate moderate dynamics of releasing metal ions; some amount of gold is detected together with silver in the solution. The absence of cytotoxicity of the synthesized film heterostructures in vitro (L-929 cells, viability >95-98%) is shown. Heterostructures completely suppress the growth of colonies of Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) bacteria after 6 h and 24 h action respectively.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0022476624080055","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Film heterostructures of compositions Ag/Au/Ti and Ag/Au/CFR-PEEK are obtained by thermal evaporation with subsequent deposition of metallic gold sublayers and silver nanostructures on modern biomaterials (Ti-6Al-4V alloy, polyether ether ketone CFR-PEEK). Silver concentration is varied within 2.1-20.8 µg/cm² by changing the initial metal portion (1.2-5 mg) and the number of successive depositions (1–3). According to SEM data, Ag nanofilms with a thickness up to 10-15 nm are formed on the surface of gold sublayers. According to XPS results, gold is present in the metallic state on the surface of biomaterials whereas along with metal, the Ag₂O oxide phase is detected for silver. The dynamics of silver dissolution from the Ag/Au surface is analyzed by ICP-AES (2-48 h). It is found that regardless of the silver concentration, the samples demonstrate moderate dynamics of releasing metal ions; some amount of gold is detected together with silver in the solution. The absence of cytotoxicity of the synthesized film heterostructures in vitro (L-929 cells, viability >95-98%) is shown. Heterostructures completely suppress the growth of colonies of Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) bacteria after 6 h and 24 h action respectively.

Abstract Image

查看原文本刊更多论文

用于植入材料功能化的银/金异质结构薄膜：成分、结构和抗菌活性

摘要通过在现代生物材料（Ti-6Al-4V 合金、聚醚醚酮 CFR-PEEK）上热蒸发并随后沉积金属金子层和银纳米结构，获得了银/金/钛和银/金/CFR-PEEK 成分的薄膜异质结构。通过改变初始金属部分（1.2-5 毫克）和连续沉积次数（1-3 次），银的浓度在 2.1-20.8 微克/平方厘米范围内变化。根据 SEM 数据，在金亚层表面形成了厚度达 10-15 纳米的银纳米薄膜。根据 XPS 结果，金以金属态存在于生物材料表面，而银除了金属态外，还检测到 Ag2O 氧化物相。ICP-AES 分析了银/金表面银溶解的动态（2-48 小时）。结果发现，无论银的浓度如何，样品都能适度地释放金属离子；在溶液中还能检测到一定量的金和银。合成的薄膜异质结构在体外没有细胞毒性（L-929 细胞，存活率为 95-98%）。异质结构分别在 6 小时和 24 小时后完全抑制了革兰氏阴性菌（绿脓杆菌）和革兰氏阳性菌（金黄色葡萄球菌）菌落的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.