Phase separation in soft repulsive polymer mixtures: foundation and implication for chromatin organization

Naoki Iso, Yuki Norizoe, Takahiro Sakaue
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Abstract

Given the wide range of length scales, the analysis of polymer systems often requires coarse-graining, for which various levels of description may be possible depending on the phenomenon under consideration. Here, we provide a super-coarse grained description, where polymers are represented as a succession of mesosopic soft beads which are allowed to overlap with others. We then investigate the phase separation behaviors in a mixture of such homopolymers based on mean-field theory, and discuss universal aspects of the miscibility phase diagram in comparison with the numerical simulation. We also discuss an extension of our analysis to mixtures involving random copolymers, which might be interesting in the context of chromatin organization in a cell nucleus.
软排斥聚合物混合物中的相分离:染色质组织的基础和含义
由于长度尺度的范围很广,聚合物体系的分析往往需要粗粒度,而根据所考虑的现象,可能需要对粗粒度进行不同程度的描述。在这里,我们提供了一种超粗粒度描述,将聚合物表示为一系列中观软珠,允许它们与其他软珠重叠。我们基于均场理论研究了此类均聚物混合物中的相分离行为,并通过与数值模拟的比较,讨论了其可溶性相图的普遍性。我们还讨论了将我们的分析扩展到涉及无规共聚物的混合物,这在细胞核内染色质组织的背景下可能会很有趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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