Connecting the dots: Involvement of methyltransferase-like 3, N6-methyladenosine modification, and ferroptosis in the pathogenesis of intracerebral hemorrhage pathogenesis

IF 4.6 2区 医学 Q1 NEUROSCIENCES
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Abstract

Intracerebral hemorrhage is a profoundly detrimental acute cerebrovascular condition with a low overall survival rate and a high post-onset disability rate. Secondary brain injury that ensues post-ICH is the primary contributor to fatality and disability. Hence, the mitigation of brain injury during intracerebral hemorrhage progression has emerged as a crucial aspect of clinical management. N6-methyladenosine is the most pervasive, abundant, and conserved internal co-transcriptional modification of eukaryotic ribonucleic acid and is predominantly expressed in the nervous system. Methyltransferase-like 3 is a key regulatory protein that is strongly associated with the development of the nervous system and numerous neurological diseases. Ferroptosis, a form of iron-associated cell death, is a typical manifestation of neuronal apoptosis in neurological diseases and plays an important role in secondary brain damage following intracerebral hemorrhage. Therefore, this review aimed to elucidate the connection between m6A modification (particularly methyltransferase-like 3) and ferroptosis in the context of intracerebral hemorrhage to provide new insights for future intracerebral hemorrhage management approaches.

Abstract Image

连接点:甲基转移酶样 3、N6-甲基腺苷修饰和铁变态反应在脑出血发病机制中的参与。
脑出血是一种危害极大的急性脑血管疾病,总体存活率低,发病后致残率高。脑出血后继发的脑损伤是导致死亡和残疾的主要原因。因此,减轻脑出血进展过程中的脑损伤已成为临床治疗的一个重要方面。N6-甲基腺苷是真核核糖核酸最普遍、最丰富、最保守的内部共转录修饰,主要在神经系统中表达。甲基转移酶样 3 是一种关键的调节蛋白,与神经系统的发育和多种神经系统疾病密切相关。铁凋亡是铁相关细胞死亡的一种形式,是神经系统疾病中神经元凋亡的典型表现,在脑出血后继发性脑损伤中起着重要作用。因此,本综述旨在阐明脑出血背景下 m6A 修饰(尤其是甲基转移酶样 3)与铁凋亡之间的联系,从而为未来的脑出血治疗方法提供新的见解。
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来源期刊
Experimental Neurology
Experimental Neurology 医学-神经科学
CiteScore
10.10
自引率
3.80%
发文量
258
审稿时长
42 days
期刊介绍: Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.
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