John DePaolo, Siavash Zamirpour, Sarah Abramowitz, Gina Biagetti, Renae Judy, Cameron Beeche, Jeffrey Duda, James Gee, Walter R. Witschey, Julio A. Chirinos, Nicholas J. Goel, Nimesh Desai, Wilson Y. Szeto, Dongchuan Guo, Dianna M. Milewicz, Michael G. Levin, James P. Pirruccello, Scott M. Damrauer
{"title":"Predicting thoracic aortic dissection in a diverse biobank using a polygenic risk score","authors":"John DePaolo, Siavash Zamirpour, Sarah Abramowitz, Gina Biagetti, Renae Judy, Cameron Beeche, Jeffrey Duda, James Gee, Walter R. Witschey, Julio A. Chirinos, Nicholas J. Goel, Nimesh Desai, Wilson Y. Szeto, Dongchuan Guo, Dianna M. Milewicz, Michael G. Levin, James P. Pirruccello, Scott M. Damrauer","doi":"10.1101/2024.09.01.24312895","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Thoracic aortic dissection is a life-threatening condition that often occurs in the presence of aortic dilation. Despite a known association between ascending aortic diameter (AscAoD) and dissection risk, predicting dissection risk remains challenging.","PeriodicalId":501297,"journal":{"name":"medRxiv - Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Cardiovascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.01.24312895","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background Thoracic aortic dissection is a life-threatening condition that often occurs in the presence of aortic dilation. Despite a known association between ascending aortic diameter (AscAoD) and dissection risk, predicting dissection risk remains challenging.
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