Tunable structural, optical and bioactive properties of magnesium and bismuth co-doping on bioactive glass nanoparticles for biomedical applications

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Research Pub Date : 2024-09-09 DOI:10.1557/s43578-024-01433-2

Divya Goel, Deenan Santhiya

{"title":"Tunable structural, optical and bioactive properties of magnesium and bismuth co-doping on bioactive glass nanoparticles for biomedical applications","authors":"Divya Goel, Deenan Santhiya","doi":"10.1557/s43578-024-01433-2","DOIUrl":null,"url":null,"abstract":"The current study focused to synthesize magnesium (Mg2+) and bismuth (Bi3+) co-doped bioactive glass (BG) nanoparticles (NPs) at ambient conditions. XPS studies confirmed the existence of Mg2+ as MgO and Bi3+ as Bi2O3 in co-doped BG NPs. XRD reported an increase in mean crystallite size from 0.1 ± 0.01 nm to 0.25 ± 0.04 nm with 0.5 to 1.5 mol% increase in Bi2O3 content. TGA revealed co-doping of Mg2+ and Bi3+ to BG NPs increased their thermal stability by 20 to 30 w/w% in comparison to the control. FTIR and NMR studies depicted open SiO2 network in co-doped BG NPs. HR-TEM evidenced co-doped BG NPs were of ~ 50 nm. The optical transmittance showed strong emission peak at 480 nm for co-doped BG NPs with decreased intensity with increasing Bi3+ ion concentration. In-vitro bioactivity, hemolysis and MTT assay revealed excellent bone binding ability, least toxicity and excellent biocompatibility.<h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":16306,"journal":{"name":"Journal of Materials Research","volume":"29 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1557/s43578-024-01433-2","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The current study focused to synthesize magnesium (Mg²⁺) and bismuth (Bi³⁺) co-doped bioactive glass (BG) nanoparticles (NPs) at ambient conditions. XPS studies confirmed the existence of Mg²⁺ as MgO and Bi³⁺ as Bi₂O₃ in co-doped BG NPs. XRD reported an increase in mean crystallite size from 0.1 ± 0.01 nm to 0.25 ± 0.04 nm with 0.5 to 1.5 mol% increase in Bi₂O₃ content. TGA revealed co-doping of Mg²⁺ and Bi³⁺ to BG NPs increased their thermal stability by 20 to 30 w/w% in comparison to the control. FTIR and NMR studies depicted open SiO₂ network in co-doped BG NPs. HR-TEM evidenced co-doped BG NPs were of ~ 50 nm. The optical transmittance showed strong emission peak at 480 nm for co-doped BG NPs with decreased intensity with increasing Bi³⁺ ion concentration. In-vitro bioactivity, hemolysis and MTT assay revealed excellent bone binding ability, least toxicity and excellent biocompatibility.

Graphical abstract

Abstract Image

查看原文本刊更多论文

在生物活性玻璃纳米粒子上共掺杂镁和铋的可调结构、光学和生物活性特性，用于生物医学应用

本研究的重点是在环境条件下合成镁（Mg2+）和铋（Bi3+）共掺杂的生物活性玻璃（BG）纳米粒子（NPs）。XPS 研究证实，在共掺杂的 BG 纳米粒子中，Mg2+ 和 Bi3+ 分别以 MgO 和 Bi2O3 的形式存在。XRD 报告称，随着 Bi2O3 含量增加 0.5 至 1.5 摩尔%，平均结晶尺寸从 0.1 ± 0.01 纳米增至 0.25 ± 0.04 纳米。热重分析表明，与对照组相比，在 BG NPs 中掺入 Mg2+ 和 Bi3+ 可使其热稳定性提高 20 至 30 w/w%。傅立叶变换红外光谱（FTIR）和核磁共振（NMR）研究表明，在共掺杂的 BG NPs 中存在开放的 SiO2 网络。HR-TEM 证明共掺杂的 BG NPs 为 ~ 50 nm。光透射率显示，共掺杂 BG NPs 在 480 纳米处有较强的发射峰，随着 Bi3+ 离子浓度的增加，发射峰强度降低。体外生物活性、溶血和 MTT 分析表明，共掺杂 BG NPs 具有优异的骨结合能力、最小的毒性和良好的生物相容性。图摘

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Materials Research 工程技术-材料科学：综合

CiteScore

4.50

自引率

3.70%

发文量

362

审稿时长

2.8 months

期刊介绍： Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory