Hemodynamics of the Frontopolar and Dorsolateral Pre-Frontal Cortex in People with Multiple Sclerosis During Walking, Cognitive Subtraction, and Cognitive-Motor Dual-Task.

IF 3.7 2区医学 Q1 CLINICAL NEUROLOGY

Neurorehabilitation and Neural Repair Pub Date : 2024-09-10 DOI:10.1177/15459683241279066

Felipe Balistieri Santinelli,Renee Veldkamp,Rodrigo Vitório,Daphne Kos,Maxine Vos,Ruth Nijssen,John DeLuca,Cintia Ramari,Peter Feys

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引用次数: 0

Abstract

INTRODUCTION Higher cortical activity has been observed in people with multiple sclerosis (pwMS) during walking and dual-tasking. However, further studies in overground walking and considering pre-frontal cortex (PFC) sub-areas are necessary. OBJECTIVES To investigate PFC activity during a cognitive-motor dual-task (DT) and its single component tasks, in combination with behavioral outcomes in pwMS. METHODS Fifteen pwMS (EDSS 3.5 [2-5.5], 42 ± 11 years) and 16 healthy controls (HC, 45.2 ± 13.2 years) performed 3 conditions: single motor-walking (SWT), single cognitive - subtracting sevens (SCT), and a DT. Meters walked and the number of correct answers were obtained from which, respectively, the motor (mDTC) and cognitive (cDTC) DT costs were calculated. A functional Near-Infrared Spectroscopy covering the frontopolar and dorsolateral PFC (DLPFC) areas was used to concentration of relative oxyhemoglobin (ΔHbO2) and deoxyhemoglobin (ΔHHb) in the PFC. A repeated 2-way ANOVA (group × conditions) was used to compare ΔHbO2/ΔHHb and behavioral outcomes. RESULTS PwMS walked shorter distances (P < .002) and answered fewer correct numbers (P < .03) than HC in all conditions, while cDTC and mDTC were similar between groups. PwMS presented higher ΔHbO2 in the frontopolar area than HC in the SWT (P < .001). HC increased ΔHbO2 in frontopolar during the SCT (P < .029) and DT (P < .037) compared with the SWT. CONCLUSION Higher frontopolar activity in pwMS compared to HC in the SWT suggests reduced gait automaticity. Furthermore, it seems that only HC increased neural activity in the frontopolar in the SCT and DT, which might suggest a limit of cognitive resources to respond to DT in pwMS.

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多发性硬化症患者在行走、认知减法和认知运动双重任务中前额极和前额背外侧皮层的血液动力学。

导言：多发性硬化症患者（pwMS）在行走和双重任务中的皮质活动较高。目的结合多发性硬化症患者的行为结果，研究认知-运动双重任务（DT）及其单项任务期间多发性硬化症患者大脑皮层的活动。方法15 名 pwMS（EDSS 3.5 [2-5.5]，42 ± 11 岁）和 16 名健康对照者（HC，45.2 ± 13.2 岁）在 3 种条件下完成了任务：单一运动-步行（SWT）、单一认知-七减七（SCT）和 DT。通过计算行走米数和正确答案数，分别得出运动（mDTC）和认知（cDTC）DT 成本。功能性近红外光谱仪覆盖了前极和背外侧前脑功能区（DLPFC），用于测定前脑功能区相对氧合血红蛋白（ΔHbO2）和脱氧血红蛋白（ΔHHb）的浓度。结果在所有条件下，PwMS 比 HC 走的距离更短（P < .002），回答的正确数字更少（P < .03），而 cDTC 和 mDTC 在组间相似。在 SWT 中，PwMS 的前极区 ΔHbO2 比 HC 高（P < .001）。与 SWT 相比，HC 在 SCT（P < .029）和 DT（P < .037）期间增加了前极区的ΔHbO2。此外，似乎只有 HC 在 SCT 和 DT 中增加了前极神经活动，这可能表明 pwMS 对 DT 作出反应的认知资源有限。

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来源期刊

Neurorehabilitation and Neural Repair 医学-康复医学

CiteScore

8.30

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.