Insights into Suture Stem Cells: Distributions, Characteristics, and Applications

IF 2.1 4区医学 Q4 CELL & TISSUE ENGINEERING

Current stem cell research & therapy Pub Date : 2024-08-28 DOI:10.2174/011574888x294038240723104727

Xiayanran Wu, Xueman Zhou, Yufan Zhu, Zhenzhen Zhang, Yanhua Dong, Jun Wang, Jin Liu

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Abstract

Stem cells play an indispensable part in bone formation, homeostasis, and regeneration. The origin of skeletal stem cells (SSCs) in long bones has been extensively discussed, and the major cell population is considered to reside in the perivascular niche of the bone marrow. Cranial bones are distinct from long bones in both the origins of their cell lineage and the manner of osteogenesis. Recently, multiple tissue-resident craniofacial stem cell populations have been identified, among which cranial suture-derived stem cells, known as suture mesenchymal stem cells (SuSCs), exhibit unique biological characteristics. Whether SuSCs have potential therapeutic uses to repair cranial bone defects and alleviate congenital skeletal diseases, represented mainly by craniosynostosis, is a question of great research value. This review focuses on craniofacial stem cells, especially SuSCs, with the goal of summarizing the latest progress as well as giving insight into their regulatory molecular mechanisms and potential therapeutic targets.

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了解缝合干细胞：分布、特征和应用

干细胞在骨骼形成、平衡和再生过程中发挥着不可或缺的作用。骨骼干细胞（SSCs）在长骨中的起源已被广泛讨论，其主要细胞群被认为存在于骨髓的血管周围生态位。颅骨在细胞系起源和成骨方式上都不同于长骨。最近，多种组织驻留的颅面干细胞群被鉴定出来，其中颅缝来源的干细胞，即缝间充质干细胞（SuSCs），表现出独特的生物学特征。SuSCs是否具有修复颅骨缺损和缓解先天性骨骼疾病（主要表现为颅骨发育不良）的潜在治疗用途，是一个极具研究价值的问题。本综述聚焦于颅面干细胞，尤其是SuSCs，旨在总结最新进展，并深入探讨其调控分子机制和潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current stem cell research & therapy CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

4.20

自引率

3.70%

发文量

197

审稿时长

>12 weeks

期刊介绍： Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research.