Evaluating the Risk of Cardiovascular Adverse Events and Appendicitis After COVID-19 Diagnosis in Adults in the United States: Implications of the Start of Follow-Up

J. Bradley Layton, Arnstein Lindaas, Stella G Muthuri, Patricia C. Lloyd, Morgan M. Richey, Joann F. Gruber, Hai Lyu, Mollie M. McKillop, Lisa S. Kowarski, Christine Bui, Shelby S. Fisher, Tainya C. Clarke, Angela S. Cheng, Zhiruo Wan, Pablo Freyria Duenas, Yangping Chen, Timothy Burrell, Minya Sheng, Azadeh Shoaibi, Yoganand Chillarige, Jeffrey Beers, Mary S. Anthony, Richard A. Forshee, Steven A. Anderson
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Abstract

Purpose This study evaluated the association between coronavirus disease 2019 (COVID-19) diagnosis and adverse events (AEs), including cardiovascular AEs and appendicitis, in US adults before the introduction of COVID-19 vaccines. Real-world studies of AEs after COVID-19 suggest that diagnoses of AEs and COVID-19 frequently occur on the same day and may be a source of bias.
评估美国成人确诊 COVID-19 后发生心血管不良事件和阑尾炎的风险:开始随访的意义
目的 本研究评估了美国成人在接种 COVID-19 疫苗前冠状病毒病 2019(COVID-19)诊断与不良事件(AEs)(包括心血管不良事件和阑尾炎)之间的关联。对 COVID-19 疫苗接种后的不良反应的实际研究表明,不良反应和 COVID-19 的诊断经常发生在同一天,这可能是造成偏差的一个原因。
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