Skeletal Reorganization: Approaches towards the Synthesis of Aza-Heterocyclic Cores

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC
Synlett Pub Date : 2024-09-12 DOI:10.1055/a-2384-6583
Dwaipayan Das, Rahul Dev Mandal, Prasun Mukherjee, Pranabes Bhattacharya, Asish R. Das
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引用次数: 0

Abstract

The impetuous development of the pharmaceutical industry and material science stimulates the search for new synthetic approaches and new methods for the synthesis and functionalization of aza-heterocycles; these are some of the key objectives of modern organic chemistry. As a result, an advanced method towards the synthesis of functionalized N-heterocycles that circumvents the limitations associated with traditional methods needs to be devised. In recent decades, rearrangement/reorganization reactions have emerged as a powerful tool for the efficient synthesis of the aza-heterocycle. In this illustration, we summarize some our recent efforts in the development of few complex aza-heterocyclic cores.

1 Introduction

2 Skeletal Rearrangement of Small Heterocycles via Domino Ring-Opening and Ring-Closing (DROC) Strategy

3 Ru(II)-Catalyzed Skeletal Rearrangement of the Quinazoline Ring

4 Lewis Acid Catalyzed Skeletal Rearrangement of Furans to Indolizine Cores

5 Skeletal Rearrangement of Donor–Acceptor Cyclopropanes via Domino Ring-Opening and Ring-Closing (DROC) Strategy

6 Lewis Acid Mediated Skeletal Rearrangement of Donor–Acceptor Spirocyclopropylpyrazolones

7 Skeletal Rearrangement through Ring Distortion Strategy

8 Conclusion

Abstract Image

骨架重组:合成氮杂环核心的方法
制药业和材料科学的迅猛发展刺激着人们寻找新的合成方法和新的氮杂环合成及功能化方法;这些是现代有机化学的一些关键目标。因此,需要设计一种先进的方法来合成功能化的 N-杂环,以规避传统方法的局限性。近几十年来,重排/重组反应已成为高效合成氮杂环的有力工具。在本说明中,我们总结了最近在开发少数复杂氮杂环核心方面所做的一些努力。1 引言 2 通过多米诺开环和闭环(DROC)策略实现小杂环的骨架重排 3 Ru(II)-Catalyzed Skeletal Rearrangement of the Quinazoline Ring 4 Lewis Acid Catalyzed Skeletal Rearrangement of Furans to Indolizine Cores 5 通过多米诺开环和闭环(DROC)策略实现供体-受体环丙烷的骨架重排。路易斯酸介导的供体-受体螺环丙基吡唑酮的骨架重排 7 通过环畸变策略实现的骨架重排 8 结论
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来源期刊
Synlett
Synlett 化学-有机化学
CiteScore
3.40
自引率
5.00%
发文量
369
审稿时长
1 months
期刊介绍: SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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