Koyeli Girigoswami, Pragya Pallavi and Agnishwar Girigoswami
{"title":"Crafting porous nanoscaled architecture as a potential frontier for drug delivery","authors":"Koyeli Girigoswami, Pragya Pallavi and Agnishwar Girigoswami","doi":"10.1039/D4ME00098F","DOIUrl":null,"url":null,"abstract":"<p >Porous nanostructures exhibit remarkable nanoplatforms for payload delivery to diseased cells with high loading capacity, favorable release profiles, improved hemocompatibility, biocompatibility, and safe clearance after biodegradation. Metal–organic frameworks (MOFs), periodic mesoporous organosilica (PMO), or biodegradable periodic mesoporous organosilica (BPMO) epitomize a similar category of structured and crystalline porous coordinated compounds or nanocomposites. Additionally, their elevated surface-to-volume ratio, customizable porous configurations, and convenient attachment of favorable ligands to the central metal ions enhance drug loading and release, further demonstrating their potential for drug delivery applications. This review focuses on these materials, including Fe-MOFs, Cu-MOFs, Zr-MOFs, PMO and BPMO, along with multicompartmental mesoporous nanostructures, detailing their specific engineering, chemistry, and optimal drug delivery applications.</p>","PeriodicalId":91,"journal":{"name":"Molecular Systems Design & Engineering","volume":" 11","pages":" 1085-1106"},"PeriodicalIF":3.2000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Systems Design & Engineering","FirstCategoryId":"5","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/me/d4me00098f","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Porous nanostructures exhibit remarkable nanoplatforms for payload delivery to diseased cells with high loading capacity, favorable release profiles, improved hemocompatibility, biocompatibility, and safe clearance after biodegradation. Metal–organic frameworks (MOFs), periodic mesoporous organosilica (PMO), or biodegradable periodic mesoporous organosilica (BPMO) epitomize a similar category of structured and crystalline porous coordinated compounds or nanocomposites. Additionally, their elevated surface-to-volume ratio, customizable porous configurations, and convenient attachment of favorable ligands to the central metal ions enhance drug loading and release, further demonstrating their potential for drug delivery applications. This review focuses on these materials, including Fe-MOFs, Cu-MOFs, Zr-MOFs, PMO and BPMO, along with multicompartmental mesoporous nanostructures, detailing their specific engineering, chemistry, and optimal drug delivery applications.
期刊介绍：
Molecular Systems Design & Engineering provides a hub for cutting-edge research into how understanding of molecular properties, behaviour and interactions can be used to design and assemble better materials, systems, and processes to achieve specific functions. These may have applications of technological significance and help address global challenges.
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