Crafting porous nanoscaled architecture as a potential frontier for drug delivery

IF 3.2 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Molecular Systems Design & Engineering Pub Date : 2024-08-22 DOI:10.1039/d4me00098f

Koyeli Girigoswami, Pragya Pallavi, Agnishwar Girigoswami

引用次数: 0

Abstract

Porous nanostructures exhibit remarkable nanoplatforms for payload delivery to diseased cells with high loading capacity, favorable release profiles, improved hemocompatibility, biocompatibility, and safe clearance after biodegradation. Metal–organic frameworks (MOFs), periodic mesoporous organosilica (PMO), or biodegradable periodic mesoporous organosilica (BPMO) epitomize a similar category of structured and crystalline porous coordinated compounds or nanocomposites. Additionally, their elevated surface-to-volume ratio, customizable porous configurations, and convenient attachment of favorable ligands to the central metal ions enhance drug loading and release, further demonstrating their potential for drug delivery applications. This review focuses on these materials, including Fe-MOFs, Cu-MOFs, Zr-MOFs, PMO and BPMO, along with multicompartmental mesoporous nanostructures, detailing their specific engineering, chemistry, and optimal drug delivery applications.

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将多孔纳米结构作为药物输送的潜在前沿领域

多孔纳米结构是向病变细胞输送有效载荷的理想纳米平台，具有高负载能力、良好的释放特性、更好的血液相容性、生物相容性以及生物降解后的安全清除性。金属有机框架（MOFs）、周期性介孔有机硅（PMO）或可生物降解周期性介孔有机硅（BPMO）是类似结构和结晶多孔配位化合物或纳米复合材料的缩影。此外，它们的表面体积比升高、可定制的多孔构型以及方便地将有利配体连接到中心金属离子上，都能提高药物的负载和释放，进一步证明了它们在药物输送应用方面的潜力。本综述将重点介绍这些材料，包括 Fe-MOFs、Cu-MOFs、Zr-MOFs、PMO 和 BPMO 以及多室介孔纳米结构，详细介绍它们的具体工程、化学和最佳药物输送应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Systems Design & Engineering Engineering-Biomedical Engineering

CiteScore

6.40

自引率

2.80%

发文量

144

期刊介绍： Molecular Systems Design & Engineering provides a hub for cutting-edge research into how understanding of molecular properties, behaviour and interactions can be used to design and assemble better materials, systems, and processes to achieve specific functions. These may have applications of technological significance and help address global challenges.