Synthesis, Photophysical Properties and Cytotoxic Activities of Isoxazole-Containing Difluoroboron Complexes

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-09-05 DOI:10.1002/jhet.4894

Kirill S. Sadovnikov, Dmitry A. Vasilenko, Nadezhda E. Astakhova, Artem S. Sazonov, Alexei A. Yakushev, Yulia A. Gracheva, Yuri K. Grishin, Victor A. Tafeenko, Elena R. Milaeva, Elena B. Averina

引用次数: 0

Abstract

A large series of previously unknown isoxazole containing difluoroboron β-diketonate has been designed and synthesized from the available starting compounds. The photophysical properties of obtained compounds were studied, and the effects of the substituents in aromatic and isoxazole cycles of the BF₂ complexes on the fluorescence were investigated. The effect of solvatochromism were demonstrated. Cytotoxic activity against MCF-7 (breast carcinoma), HCT-116 (colon carcinoma), A549 (pulmonary carcinoma) and WI38 (fibroblasts from lung tissue) cell lines was tested and moderate toxicity in the concentration range of 10–100 μM was found for several compounds.

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含异噁唑的二氟硼络合物的合成、光物理性质和细胞毒活性

从现有的起始化合物中设计并合成了一大系列以前未知的含有二氟硼 β-二酮的异噁唑。研究了所获化合物的光物理特性，并考察了 BF2 复合物中芳香和异噁唑周期取代基对荧光的影响。研究还证明了溶解色素的影响。对 MCF-7（乳腺癌）、HCT-116（结肠癌）、A549（肺癌）和 WI38（肺组织成纤维细胞）细胞系的细胞毒活性进行了测试，发现几种化合物在 10-100 μM 浓度范围内具有中等毒性。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.