Case reports of immune-related cystitis and the antibody combination hypothesis.

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-09-12 DOI:10.1080/1750743x.2024.2389761

Peng Zhang,Chunyan Yin,Ming Yang

引用次数: 0

Abstract

Immune-related cystitis is a rare condition, and its diagnostic criteria and pathogenesis are not yet fully understood. Here, we report two cases of immune-related cystitis. Both patients were previously diagnosed with lung squamous cell carcinoma and received combined treatment with immune checkpoint inhibitors and chemotherapy, leading to hemorrhagic cystitis. We reviewed the cystoscopic images and pathological features of previous cases and found that autoantibodies against hemidesmosomes may be the cause of immune-related cystitis, proposing the "antibody combination" hypothesis to explain the tissue specificity of the condition.

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免疫相关性膀胱炎病例报告与抗体组合假说。

免疫相关性膀胱炎是一种罕见疾病，其诊断标准和发病机制尚未完全明了。在此，我们报告了两例免疫相关性膀胱炎病例。这两名患者之前都被诊断为肺鳞癌，并接受了免疫检查点抑制剂和化疗的联合治疗，导致出血性膀胱炎。我们回顾了以往病例的膀胱镜图像和病理特征，发现针对半球体的自身抗体可能是免疫相关性膀胱炎的病因，并提出了 "抗体组合 "假说来解释该病症的组织特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.