Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey

IF 2.9 3区医学 Q3 NUTRITION & DIETETICS

Journal of Human Nutrition and Dietetics Pub Date : 2024-09-10 DOI:10.1111/jhn.13366

Dehua Zhao, Xiaoqing Long, Jisheng Wang

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引用次数: 0

Abstract

Background

Previous studies indicate that vitamin C may decrease the occurrence and intensity of migraines, but the evidence is restricted due to small sample sizes. This study aimed to determine the magnitude of the association between dietary vitamin C intake and migraine in the general population.

Methods

This cross-sectional study utilised data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2004. Participants who had severe headaches or migraines in the past 3 months were classified as experiencing migraines. Dietary vitamin C intake was evaluated using the 24-h dietary recall system. Logistic regression models, restricted cubic spline (RCS) regression and stratified analyses were employed to assess the association between dietary vitamin C intake and migraine.

Results

The study included 4101 participants, of whom 702 (17.12%) experienced migraine. The study revealed an inverse association between dietary vitamin C intake and migraine (odds ratio [OR] = 0.89, 95% confidence intervals [CI] = 0.83–0.96, p = 0.002) after adjusting for demographic covariates, lifestyle covariates, laboratory tests, physical examinations, physical activity, dietary covariates and comorbidities. When vitamin C intake was categorised, the adjusted OR (95% CI) for migraine in Q4 (highest vitamin C intake) was 0.64 (95% CI = 0.49–0.84, p = 0.001) compared to Q1 (lowest vitamin C intake). The RCS regression showed a linear inverse relationship between dietary vitamin C intake and migraine (p_{non-linearity} = 0.449). The findings remained consistent, and no significant interactions were found among different groups.

Conclusions

Dietary vitamin C intake was inversely associated with migraine, and a linear negative relationship was found between vitamin C intake and migraine.

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膳食维生素 C 摄入量与成人偏头痛之间的关系：国家健康与营养调查的一项横断面研究

背景以往的研究表明，维生素 C 可降低偏头痛的发生率和强度，但由于样本量较小，证据有限。这项研究旨在确定普通人群膳食维生素 C 摄入量与偏头痛之间的关联程度。方法这项横断面研究利用了 1999 年至 2004 年间进行的美国国家健康与营养调查（NHANES）的数据。在过去 3 个月中出现过严重头痛或偏头痛的参与者被归类为偏头痛患者。膳食中维生素 C 的摄入量通过 24 小时膳食回忆系统进行评估。研究采用了逻辑回归模型、限制性立方样条线（RCS）回归和分层分析来评估膳食维生素 C 摄入量与偏头痛之间的关系。在对人口统计学协变量、生活方式协变量、实验室检测、体格检查、体力活动、饮食协变量和合并症进行调整后，研究发现膳食维生素C摄入量与偏头痛之间存在负相关（几率比[OR]=0.89，95%置信区间[CI]=0.83-0.96，P=0.002）。如果对维生素C的摄入量进行分类，与第一季度（维生素C摄入量最低）相比，第四季度（维生素C摄入量最高）偏头痛的调整OR值（95% CI）为0.64（95% CI = 0.49-0.84，p = 0.001）。RCS回归结果显示，膳食维生素C摄入量与偏头痛之间呈线性反比关系（p非线性=0.449）。结论膳食维生素 C 摄入量与偏头痛成反比，维生素 C 摄入量与偏头痛之间呈线性负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.