Raylane Adrielle Gonçalves Cambui, Mariela Estefany Vera Roa, Vinicius Nunes Cordeiro Leal, Suemy Melim Yamada, Leonardo Antônio Teixeira de Oliveira, Izabel Nazira Nadaf, Cleiton Ribeiro Lelis, Rafaela Cássia da Cunha Pedroso, Rafaela Cardoso do Nascimento Costa, Raquel Maria Neves Amorim, Jefferson Rodrigues do Amaral, Polyana Silva Lemes, Leonardo Amorim Rizzo, Gilmar Ferreira do Espírito Santo, Rosa Maria Elias, Bruno Cogliati, Marcelo Hill, Alessandra Pontillo
{"title":"Inverse correlation between NLRP3 and TMEM176B as a possible tool for colorectal cancer progression","authors":"Raylane Adrielle Gonçalves Cambui, Mariela Estefany Vera Roa, Vinicius Nunes Cordeiro Leal, Suemy Melim Yamada, Leonardo Antônio Teixeira de Oliveira, Izabel Nazira Nadaf, Cleiton Ribeiro Lelis, Rafaela Cássia da Cunha Pedroso, Rafaela Cardoso do Nascimento Costa, Raquel Maria Neves Amorim, Jefferson Rodrigues do Amaral, Polyana Silva Lemes, Leonardo Amorim Rizzo, Gilmar Ferreira do Espírito Santo, Rosa Maria Elias, Bruno Cogliati, Marcelo Hill, Alessandra Pontillo","doi":"10.1101/2024.08.30.24312793","DOIUrl":null,"url":null,"abstract":"<strong>Purpose</strong> TMEM176B has been recently identified as a novel player in anti-cancer immune responses by negatively modulating the NLRP3 inflammasome activation in colorectal cancer (CRC). Yet, the TMEM176B/NLRP3 axis in CRC needs to be deeply investigated.","PeriodicalId":501437,"journal":{"name":"medRxiv - Oncology","volume":"21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.30.24312793","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Purpose TMEM176B has been recently identified as a novel player in anti-cancer immune responses by negatively modulating the NLRP3 inflammasome activation in colorectal cancer (CRC). Yet, the TMEM176B/NLRP3 axis in CRC needs to be deeply investigated.
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