Associations of prognostic nutritional index with risk of all-cause and cardiovascular disease mortalities in persons with gestational diabetes mellitus: A NHANES-based analysis

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2024-09-10 DOI:10.1177/14791641241284409

Jianfang Cao, Xiao Bu, Juping Chen, Xia Zhang

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引用次数: 0

Abstract

ObjectiveTo investigate relationships between prognostic nutritional index (PNI) during pregnancy and risk of all-cause mortality (ACM) and cardiovascular disease (CVD) mortality in persons with gestational diabetes mellitus (GDM).MethodsA cross-sectional study was conducted using NHANES data from 2007 to 2018, and weighted Cox regression models were established. Restricted cubic spline analysis was used to unveil associations of PNI with risk of ACM and CVD mortalities in individuals with GDM. Receiver operating characteristic curve was employed for determination of threshold value for association of PNI with mortality. Sensitivity analysis was performed to verify the stability of the results.Results734 GDM individuals and 7987 non-GDM individuals were included in this study. In GDM population, after adjusting for different categorical variables, PNI was significantly negatively correlated with ACM risk. Subgroup analysis showed that among GDM populations with no physical activity, moderate physical activity, parity of 1 or 2, negative correlation between PNI and risk of ACM was stronger than other subgroups. Sensitivity analysis results showed stable negative correlations between PNI and ACM and CVD mortality of total population, and between PNI and ACM of GDM.ConclusionIn individuals with GDM, PNI was negatively correlated with ACM risk, especially in populations with no physical activity, moderate physical activity, and parity of 1 or 2. PNI = 50.75 may be an effective threshold affecting ACM risk in GDM, which may help in risk assessment and timely intervention for individuals with GDM.

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妊娠期糖尿病患者的预后营养指数与全因和心血管疾病死亡风险的关系：基于 NHANES 的分析

目的探讨妊娠期预后营养指数（PNI）与妊娠期糖尿病（GDM）患者全因死亡（ACM）和心血管疾病（CVD）死亡风险之间的关系。方法利用 2007 年至 2018 年的 NHANES 数据进行横断面研究，并建立加权 Cox 回归模型。采用限制立方样条分析揭示了 PNI 与 GDM 患者 ACM 和 CVD 死亡风险的关联。采用接收者操作特征曲线确定 PNI 与死亡率相关性的阈值。研究还进行了敏感性分析，以验证结果的稳定性。在 GDM 群体中，在对不同的分类变量进行调整后，PNI 与 ACM 风险呈显著负相关。亚组分析表明，在无体力活动、中等体力活动、奇偶数为 1 或 2 的 GDM 群体中，PNI 与 ACM 风险之间的负相关性强于其他亚组。敏感性分析结果显示，总人口的 PNI 和 ACM 与心血管疾病死亡率之间以及 GDM 的 PNI 和 ACM 之间存在稳定的负相关。PNI = 50.75 可能是影响 GDM ACM 风险的有效阈值，有助于对 GDM 患者进行风险评估和及时干预。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)