Design and optimization of refractive index biosensor for MDA-MB-231 and MCF-7 breast cancer biomarker detection

IF 2.6 3区物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY

Physica Scripta Pub Date : 2024-09-10 DOI:10.1088/1402-4896/ad74ac

Trupti Kamani, Shobhit K Patel, Osamah Alsalman and Faisal Alsaif

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引用次数: 0

Abstract

Breast cancer is the leading malignancy in women and the 2nd widespread cancer globally. Earlier identification of breast cancer can improve treatment outcomes and prevent metastasis beyond the breast. Traditional screening tests are not sensitive enough for early diagnosis and have extended detection periods. Recent studies have explored diversified Breast cancer biosensor techniques, including optical, electrical, electrochemical, and mechanical biosensors. This paper nominates a circlet with a large plus sign refraction indices biosensor for the evaluation of two distinct breast cancer cells namely, MDA-MB-231 and MCF-7. The supreme sensitivity has been viewed as 1714.28 nm/RIU for the MDA-MB-231 and 1714.28 nm/RIU for the MCF-7. The supreme quality factor (QF) value for UC1(usual cell of MDA-MB-231) is 10.52, for CC1(cancer cell of MDA-MB-231) is 11.94, for UC2 (usual cell of MCF-7) is 10.64, and for CC2 (cancer cell of MCF-7) is 12.09. The minimal detection value (DL) for UC1 is 0.1573, CC1 is 0.1360, UC2 is 0.1554, and CC2 is 0.1341. This nominated sensor has the potential to sense breast tumor biomarkers.

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设计和优化用于检测 MDA-MB-231 和 MCF-7 乳腺癌生物标记物的折射率生物传感器

乳腺癌是女性的头号恶性肿瘤，也是全球第二大常见癌症。及早发现乳腺癌可以改善治疗效果，防止乳腺癌转移到乳腺以外的部位。传统的筛查测试对早期诊断不够敏感，而且检测周期较长。最近的研究探索了多种乳腺癌生物传感器技术，包括光学、电学、电化学和机械生物传感器。本文提出了一种具有大正号折射率的环形生物传感器，用于评估两种不同的乳腺癌细胞，即 MDA-MB-231 和 MCF-7。MDA-MB-231 的最高灵敏度为 1714.28 nm/RIU，MCF-7 的最高灵敏度为 1714.28 nm/RIU。UC1（MDA-MB-231 的普通细胞）的最高质量因子 (QF) 值为 10.52，CC1（MDA-MB-231 的癌细胞）为 11.94，UC2（MCF-7 的普通细胞）为 10.64，CC2（MCF-7 的癌细胞）为 12.09。UC1 的最小检测值 (DL) 为 0.1573，CC1 为 0.1360，UC2 为 0.1554，CC2 为 0.1341。这种被提名的传感器具有检测乳腺肿瘤生物标记物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physica Scripta 物理-物理：综合

CiteScore

3.70

自引率

3.40%

发文量

782

审稿时长

4.5 months

期刊介绍： Physica Scripta is an international journal for original research in any branch of experimental and theoretical physics. Articles will be considered in any of the following topics, and interdisciplinary topics involving physics are also welcomed: -Atomic, molecular and optical physics- Plasma physics- Condensed matter physics- Mathematical physics- Astrophysics- High energy physics- Nuclear physics- Nonlinear physics. The journal aims to increase the visibility and accessibility of research to the wider physical sciences community. Articles on topics of broad interest are encouraged and submissions in more specialist fields should endeavour to include reference to the wider context of their research in the introduction.