Stephen Joza, Aline Delva, Christina Tremblay, Andrew Vo, Marie Filiatrault, Max Tweedale, John-Paul Taylor, John T. O’Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Johannes Klein, Michele Hu, Petr Dusek, Stanislav Marecek, Zsoka Varga, Stephane Lehericy, Isabelle Arnulf, Marie Vidailhet, Jean-Christophe Corvol, Jean-François Gagnon, Ronald B. Postuma, Alain Dagher, Richard Camicioli, Howard Chertkow, Simon Lewis, Elie Matar, Kaylena A. Ehgoetz Martens, Lachlan Churchill, Michael Sommerauer, Sinah Röttgen, Per Borghammer, Karoline Knudsen, Allan K. Hansen, Dario Arnaldi, Beatrice Orso, Pietro Mattioli, Luca Roccatagliata, Oury Monchi, Shady Rahayel
{"title":"Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder","authors":"Stephen Joza, Aline Delva, Christina Tremblay, Andrew Vo, Marie Filiatrault, Max Tweedale, John-Paul Taylor, John T. O’Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Johannes Klein, Michele Hu, Petr Dusek, Stanislav Marecek, Zsoka Varga, Stephane Lehericy, Isabelle Arnulf, Marie Vidailhet, Jean-Christophe Corvol, Jean-François Gagnon, Ronald B. Postuma, Alain Dagher, Richard Camicioli, Howard Chertkow, Simon Lewis, Elie Matar, Kaylena A. Ehgoetz Martens, Lachlan Churchill, Michael Sommerauer, Sinah Röttgen, Per Borghammer, Karoline Knudsen, Allan K. Hansen, Dario Arnaldi, Beatrice Orso, Pietro Mattioli, Luca Roccatagliata, Oury Monchi, Shady Rahayel","doi":"10.1101/2024.09.05.24313131","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Synucleinopathies manifest as a spectrum of disorders that vary in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) and dementia with Lewy bodies. Patterns of brain atrophy in iRBD are already reminiscent of what is later seen in overt disease and are related to cognitive impairment, being associated with the development of dementia with Lewy bodies. However, how brain atrophy begins and progresses remains unclear.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.05.24313131","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background Synucleinopathies manifest as a spectrum of disorders that vary in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) and dementia with Lewy bodies. Patterns of brain atrophy in iRBD are already reminiscent of what is later seen in overt disease and are related to cognitive impairment, being associated with the development of dementia with Lewy bodies. However, how brain atrophy begins and progresses remains unclear.
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