Associations Between Blood Markers of the GSH Redox cycle and Brain White Matter Microstructure in Psychosis

Tommaso Pavan, Pascal Steullet, Yasser Alemán-Gómez, Raoul Jenni, Zoé Schilliger, Martine Cleusix, Luis Alameda, Kim Q. Do, Philippe Conus, Patric Hagmann, Daniella Dwir, Paul Klauser, Ileana Jelescu
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Abstract

In groups of patients suffering from psychosis, redox dysregulation was reported in both peripheral fluids and brain. It has been hypothesized that such dysregulation, including alterations of the glutathione (GSH) cycle could participate in the brain white matter (WM) abnormalities in schizophrenia (SZ) due to the oligodendrocytes’ susceptibility to oxidative stress (OxS).
精神病患者血液中 GSH 氧化还原循环标记物与大脑白质微结构之间的关系
据报道,在精神病患者群体中,外周体液和大脑中都存在氧化还原失调现象。据推测,由于少突胶质细胞易受氧化应激(OxS)的影响,这种失调(包括谷胱甘肽(GSH)循环的改变)可能与精神分裂症(SZ)的脑白质(WM)异常有关。
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