Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery?

Antibiotics Pub Date : 2024-09-04 DOI:10.3390/antibiotics13090841

Shubham Yashwant Dakhode, Woo Sub Kim, Hyun Jin Kim, Seung Yeol Lee

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Abstract

Taurolidine, known for its broad-spectrum antimicrobial properties and low toxicity, has shown promise in reducing infections in various surgical settings. However, it has not been extensively evaluated in orthopedic surgery. This study assessed the efficacy of taurolidine irrigation in reducing surgical site infections in patients undergoing ankle fracture surgery. A retrospective review was conducted for patients >20 years old who underwent ankle fracture surgery between March 2016 and March 2023, with follow-ups exceeding 6 months. Patients were classified into the following two groups: those who underwent normal saline (NS) irrigation and those who underwent taurolidine irrigation. Minor infections were defined as requiring additional oral antibiotics postoperatively, while major infections were characterized by hospitalization or reoperation due to infection within 3 months. Of 844 patients, 688 were included. The taurolidine group (n = 328) had a significant reduction in minor infections (7.3% vs. 22.5%, odds ratio = 0.410, p = 0.028) compared to the NS group (n = 360). Major infections were fewer in the NS group (1.2% vs. 0%, p = 0.051), but the number of cases was too small for reliable analysis. Taurolidine irrigation significantly reduces the occurrence of minor infections in ankle fracture surgeries when compared to normal saline irrigation.

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Taurolidine 冲洗对预防骨折手术中的手术部位感染有效吗？

滔罗尼定以其广谱抗菌特性和低毒性而闻名，在减少各种手术环境中的感染方面显示出良好的前景。然而，在骨科手术中尚未对其进行广泛评估。本研究评估了滔罗匹定冲洗对减少踝关节骨折手术患者手术部位感染的疗效。研究人员对 2016 年 3 月至 2023 年 3 月期间接受踝关节骨折手术的 20 岁以上患者进行了回顾性研究，随访时间超过 6 个月。患者被分为以下两组：接受生理盐水（NS）冲洗的患者和接受妥洛尼定（taurolidine）冲洗的患者。轻度感染的定义是术后需要额外口服抗生素，而重度感染的特征是 3 个月内因感染住院或再次手术。在 844 名患者中，有 688 人被纳入研究。与 NS 组（n = 360）相比，他乐定组（n = 328）的轻度感染显著减少（7.3% vs. 22.5%，几率比 = 0.410，p = 0.028）。NS 组的严重感染率较低（1.2% 对 0%，p = 0.051），但病例数太少，无法进行可靠的分析。与普通生理盐水冲洗相比，妥洛尼定冲洗可明显减少踝关节骨折手术中轻微感染的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibiotics

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