In-silico study on cumulative effects of degeneration and anterior circumferential annular tear on the L5-S1 spinal unit

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Vinyas, Subraya Krishna Bhat, Hiroshi Yamada and N Shyamasunder Bhat
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引用次数: 0

Abstract

Low back pain is a serious health concern prevalent in majority of the people around the world, especially in case of the elderly. The root cause for this is mostly observed to be the development of lesions/ tears complemented by degenerative effects in the intervertebral disc of L4-L5 and L5-S1 segments. This study aims to analyse the effects of disc degeneration and tears on the mechanical responses of the L5-S1 spinal unit, which has not been investigated. The annulus is represented by an anisotropic hyperelastic Gasser-Ogden-Holzapfel (GOH) model wherein the effect of degeneration is defined by varying the constants responsible for the behaviour of the material in different strain-ranges. A systematic approach is proposed for modelling the effects of disc degeneration in the annulus. Further, the commonly found anterior circumferential tear is modelled to understand its combined effects with degeneration of the annulus. The damaging effect of the tear was limited only to extension movement, causing critical stress variations in its vicinity. However, degeneration had a significant influence on both stress and range of motion of the spinal unit across all types of movements. This study highlights the complex relationship of the physiological movements with pathogenesis of tear and degeneration leading to discogenic pain thus enabling clinicians to develop conservative treatment strategies for specific age groups.
关于 L5-S1 脊柱单元退变和前环状撕裂累积效应的模拟研究
腰痛是世界上大多数人,尤其是老年人普遍存在的严重健康问题。据观察,其根本原因主要是 L4-L5 和 L5-S1 节段的椎间盘发生病变/撕裂,并伴有退行性影响。本研究旨在分析椎间盘退化和撕裂对 L5-S1 脊柱单元机械反应的影响。椎间盘环由各向异性超弹性的 Gasser-Ogden-Holzapfel (GOH) 模型表示,通过改变不同应变范围内材料行为的常数来定义退化的影响。本文提出了一种系统的方法来模拟椎间盘退变对环面的影响。此外,还对常见的前圆周撕裂进行了建模,以了解其与椎间盘环退化的综合影响。撕裂的破坏作用仅限于伸展运动,导致其附近的临界应力变化。然而,在所有类型的运动中,退化对脊柱单元的应力和运动范围都有显著影响。这项研究强调了生理运动与导致椎间盘源性疼痛的撕裂和退化的发病机制之间的复杂关系,从而使临床医生能够针对特定年龄组制定保守治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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