Non-Coding RNAs Involved in the Regulation of Signaling Pathways as Possible Markers of Non-Alcoholic Fatty Liver Disease Progression

IF 0.5 4区 生物学 Q4 BIOLOGY
L. V. Topchieva, I. V. Kurbatova, O. P. Dudanova, A. V. Vasilyeva, G. A. Zhulay
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引用次数: 0

Abstract

The current understanding of the role of non-coding RNAs in the regulation of signaling pathways that control lipid accumulation and the development of inflammation in non-alcoholic fatty liver disease (NAFLD) is outlined. The contribution of peroxisome proliferator-activated receptors (PPARs) to changes in lipid metabolism and the formation of lipotoxicity as trigger mechanisms of NAFLD is considered. The role of TGFβ, TNFα/NF-κb, IL-6/JAK/STAT3 signaling pathways in the activation of stellate cells, liver fibrogenesis and the progression of NAFLD has been demonstrated. Analysis of literature data has revealed a number of microRNAs and long non-coding RNAs (lncRNAs) presumably associated with the regulation of these signaling pathways in this disease. They may probably have prognostic significance for differentiating clinical forms and severity of NAFLD.

Abstract Image

参与信号通路调控的非编码 RNA 可能是非酒精性脂肪肝进展的标志物
摘要 概述了非编码 RNA 在调控非酒精性脂肪性肝病(NAFLD)中控制脂质积累和炎症发展的信号通路中的作用。研究考虑了过氧化物酶体增殖激活受体(PPARs)对非酒精性脂肪肝的脂质代谢变化和脂毒性形成的作用。TGFβ、TNFα/NF-κb、IL-6/JAK/STAT3 信号通路在星状细胞活化、肝纤维化和非酒精性脂肪肝进展中的作用已得到证实。对文献数据的分析表明,一些 microRNA 和长非编码 RNA(lncRNA)可能与该疾病中这些信号通路的调控有关。它们可能对区分非酒精性脂肪肝的临床形式和严重程度具有预后意义。
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来源期刊
Biology Bulletin
Biology Bulletin 生物-生物学
CiteScore
0.70
自引率
20.00%
发文量
84
审稿时长
4-8 weeks
期刊介绍: Biology Bulletin (Izvestiya Rossiiskoi Akademii Nauk – Seriya Biologicheskaya) is an interdisciplinary journal of general biology. It focuses on fundamental studies in the fields of cell biology, biochemistry, zoology, botany, physiology, and ecology. This journal publishes current materials of experimental studies and surveys on current problems in general biology. It also publishes information on scientific conferences and new books in the fields of general biology.
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