Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes

IF 6.4 1区生物学 Q1 BIOLOGY

eLife Pub Date : 2024-09-11 DOI:https://doi.org/10.7554/elife.94317.3

Jialin Li, Feihong Yang, Yu Tian, Ziwu Wang, Dashi Qi, Zhengang Yang, Jiangang Song, Jing Ding, Xin Wang, Zhuangzhi Zhang

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引用次数: 0

Abstract

The emergence of myelinating oligodendrocytes represents a pivotal developmental milestone in vertebrates, given their capacity to ensheath axons and facilitate the swift conduction of action potentials. It is widely accepted that cortical oligodendrocyte progenitor cells (OPCs) arise from medial ganglionic eminence (MGE), lateral/caudal ganglionic eminence (LGE/CGE), and cortical radial glial cells (RGCs). Here, we used two different fate mapping strategies to challenge the established notion that the LGE generates cortical OPCs. Furthermore, we used a Cre/loxP-dependent exclusion strategy to reveal that the LGE/CGE does not give rise to cortical OPCs. Additionally, we showed that specifically eliminating MGE-derived OPCs leads to a significant reduction of cortical OPCs. Together, our findings indicate that the LGE does not generate cortical OPCs, contrary to previous beliefs. These findings provide a new view of the developmental origins of cortical OPCs and a valuable foundation for future research on both normal development and oligodendrocyte-related disease.

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侧/尾神经节突起对皮质少突胶质细胞的贡献有限

在脊椎动物中，髓鞘化少突胶质细胞的出现是一个关键的发育里程碑，因为它们有能力鞘套轴突并促进动作电位的快速传导。人们普遍认为，皮质少突胶质细胞祖细胞（OPCs）来源于内侧神经节突起（MGE）、外侧/中央神经节突起（LGE/CGE）和皮质放射状胶质细胞（RGCs）。在这里，我们使用了两种不同的命运图谱策略来挑战 LGE 产生皮质 OPC 的既定观点。此外，我们还使用了一种依赖 Cre/loxP 的排除策略，揭示了 LGE/CGE 不会产生皮质 OPCs。此外，我们还发现，特异性消除 MGE 衍生的 OPCs 会导致大脑皮层 OPCs 的显著减少。总之，我们的研究结果表明，LGE 不会产生皮质 OPC，这与之前的观点相反。这些发现为大脑皮层 OPC 的发育起源提供了新的视角，并为今后研究正常发育和少突胶质细胞相关疾病奠定了宝贵的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

eLife BIOLOGY-

CiteScore

12.90

自引率

3.90%

发文量

3122

审稿时长

17 weeks

期刊介绍： eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.