Utility of a patient-specific aperture collimator and multi-leaf collimator in line scanning proton therapy

IF 0.8 4区 物理与天体物理 Q3 PHYSICS, MULTIDISCIPLINARY
Mincheol Ko, Chanil Jeon, Sung Hwan Ahn, Youngyih Han, Kwangzoo Chung, Sungkoo Cho, Kwanghyun Jo, Eun Hyuk Shin, Sehyoung Lee, WooJin Lee, Yoonjin Oh, Juhye Kim, Seokyoon Kang, Hee Chul Park, Kisung Lee
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Abstract

Scanning proton therapy offers advantages over conventional photon therapy due to the Bragg-peak effect and superior dosimetric precision. Compared with passive methods, however, scanning proton therapy tends to exhibit a wider penumbra in the low-energy range. To address this issue, the present study evaluated the effectiveness of a patient-specific aperture collimator (AC) and multi-leaf collimator (MLC) for the line proton scanning treatment system at the Samsung Proton Therapy Center in Korea. The penumbra reduction efficiency of the collimation devices and the neutron dose was assessed through Monte Carlo (MC) simulations. The clinical effectiveness was evaluated dosimetrically and by assessing quality assurance. Through the MC calculation, the AC displayed the highest efficiency in penumbra reduction (43.75% of no collimator’s penumbra width at a depth of 10 cm with a 150 MeV proton beam), while the MLC also presented a comparable effect (56.25%). The neutron dose was compared at varying distances from the field edge. The neutron dose was higher in the order of AC(+ 11.96%p), MLC(+ 2.61%p), and no collimator at the 10 cm distance from field edge. For the dosimetric study, treatment plans for the nasal cavity, prostate, liver, lungs, and breasts were generated by the treatment planning system using the MC algorithm. Three treatment plans were developed for each of these five sites: line scanning without any collimation, line scanning with patient-specific ACs, and line scanning with MLCs. These plans were then compared dosimetrically, and gamma pass-rates were measured at various depths. These multifaceted comparisons showed that the use of an AC optimized the OAR sparing effect, with an MLC having similar effects, while maintaining the same target coverage and producing less neutron dose. All measurement results demonstrated a gamma pass-rate (2%, 2 mm) of over 90%, indicating the feasibility of implementing these techniques in actual clinical practice.

Abstract Image

患者专用孔径准直器和多叶准直器在线性扫描质子疗法中的应用
与传统光子疗法相比,扫描质子疗法具有布拉格峰效应和更高的剂量测定精度等优势。然而,与被动方法相比,扫描质子疗法在低能量范围内往往表现出更宽的半影。为了解决这个问题,本研究评估了韩国三星质子治疗中心的质子扫描治疗系统中患者专用孔径准直器(AC)和多叶准直器(MLC)的有效性。通过蒙特卡洛(MC)模拟评估了准直装置的半影减少效率和中子剂量。临床效果通过剂量学和质量保证评估进行了评价。通过 MC 计算,AC 在减少半影方面的效率最高(在 150 MeV 质子束作用下,10 厘米深度处的半影宽度是无准直器半影宽度的 43.75%),而 MLC 的效果也相当(56.25%)。比较了距离场边缘不同距离的中子剂量。在距离磁场边缘 10 厘米处,中子剂量依次为 AC(+ 11.96%p)、MLC(+ 2.61%p)和无准直器。在剂量测定研究中,治疗计划系统使用 MC 算法生成了鼻腔、前列腺、肝脏、肺部和乳房的治疗计划。为这五个部位分别制定了三种治疗方案:无准直的线扫描、带有患者特定 AC 的线扫描和带有 MLC 的线扫描。然后对这些方案进行剂量学比较,并测量了不同深度的伽马通过率。这些多方面的比较结果表明,使用 AC 可以优化 OAR 的疏通效果,而使用 MLC 也有类似的效果,同时还能保持相同的目标覆盖范围,并产生较少的中子剂量。所有测量结果均显示伽马通过率(2%,2 毫米)超过 90%,这表明在实际临床实践中采用这些技术是可行的。
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来源期刊
Journal of the Korean Physical Society
Journal of the Korean Physical Society PHYSICS, MULTIDISCIPLINARY-
CiteScore
1.20
自引率
16.70%
发文量
276
审稿时长
5.5 months
期刊介绍: The Journal of the Korean Physical Society (JKPS) covers all fields of physics spanning from statistical physics and condensed matter physics to particle physics. The manuscript to be published in JKPS is required to hold the originality, significance, and recent completeness. The journal is composed of Full paper, Letters, and Brief sections. In addition, featured articles with outstanding results are selected by the Editorial board and introduced in the online version. For emphasis on aspect of international journal, several world-distinguished researchers join the Editorial board. High quality of papers may be express-published when it is recommended or requested.
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