S Ma, MC Morris, MJ Hubal, LM Ross, KM Huffman, CG Vann, N Moore, ER Hauser, A Bareja, R Jiang, E Kummerfeld, MD Barberio, JA Houmard, WB Bennett, JL Johnson, JA Timmons, G Broderick, VB Kraus, CF Aliferis, WE Kraus
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Abstract
BACKGROUND Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle gene expression. The analysis considers differences by biological sex, exercise amount, and exercise intensity to identify potential molecular targets for developing pharmacologic agents that replicate the health benefits of exercise.
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