Modeling the Toxicokinetics of Suspensions of Soluble Metallic Nanomaterials

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-09-09 DOI:10.1021/acs.chemrestox.4c00177

Guangchao Chen, Vivi Rottschäfer, Martina G. Vijver, Willie J. G. M. Peijnenburg

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引用次数: 0

Abstract

Proper risk assessment of the many new nanoforms (NFs) that are currently being developed and marketed is hindered by constraints in time and resources for testing their fate and (eco) toxicity profile. This problem has also been encountered in conventional chemical risk assessments, where the definition of related chemical groups can facilitate risk assessment for all class members. Whereas grouping and read-across methods are well established, such approaches are in the early stages of development for NFs. In this study, a modeling framework was developed for grouping NFs into distinct classes regarding the contribution of released ions to suspension-induced toxicity. The framework is based on combining dissolution rate constants of NFs with information about the toxicokinetics of the NFs and the dissolution products formed. The framework is exemplified for the specific case of suspension toxicity of metallic NFs (silver and copper). To this end, principles of mixture toxicity and dose–response modeling are integrated to derive threshold values for the key NF properties determining suspension toxicity: size, shape, and chemical composition. The threshold values thus derived offer a possible solution for the high-throughput screening of NFs according to their morphological and compositional properties in a regulatory context.

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可溶性金属纳米材料悬浮液的毒物动力学建模

由于时间和资源的限制，无法对目前正在开发和销售的许多新纳米形式（NFs）的命运和（生态）毒性概况进行测试，因此无法对其进行适当的风险评估。在传统的化学品风险评估中也遇到了这个问题，相关化学品组的定义有助于对所有类别成员进行风险评估。虽然分组和交叉阅读的方法已经非常成熟，但针对无机氟化合物的此类方法还处于早期开发阶段。在本研究中，针对释放离子对悬浮诱导毒性的贡献，开发了一个将无机氟化合物分为不同类别的建模框架。该框架的基础是将无机氟化物的溶解速率常数与无机氟化物和所形成的溶解产物的毒物动力学信息相结合。该框架以金属 NF（银和铜）的悬浮毒性这一特定案例为例进行说明。为此，将混合物毒性原理与剂量反应模型相结合，推导出决定悬浮毒性的关键 NF 特性的阈值：尺寸、形状和化学成分。由此得出的阈值为在监管背景下根据 NF 的形态和组成特性对其进行高通量筛选提供了可能的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.