An Insight into Immunological Therapeutic Approach against Cancer: Potential Anti-Cancer Vaccines

IF 1.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Arjun Singh Kohli, Somali Sanyal, Radhey Shyam Kaushal, Manish Dwivedi
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引用次数: 0

Abstract

The development of a cancer vaccine comes with its complications and designing and developing a vaccine against foreign invaders such as bacterial and viral particles is not as complex and multi-faceted as the preparation of immunotherapy for host-infected cells which resemble our own body cells. The entire research and development framework of designing a vaccine for cancerous cells lies entirely on the remarkable aspect of notifying specific interactions and acclimatising the immune system. This review aims to compile the several fronts research-based methodology applies to in terms of developing a therapeutic, preventive or personalised vaccine for cancer . The approach lays focus on the identification and selection of targets for vaccine development which have come to light as immune biomarkers. Furthemore, significant aspects of personalised and precision vaccines and the fine line that runs between these approaches have also been discussed.
洞察抗癌免疫疗法:潜在的抗癌疫苗
癌症疫苗的开发有其复杂性,针对细菌和病毒颗粒等外来入侵者的疫苗设计和开发不如针对类似于自身体细胞的宿主感染细胞的免疫疗法的准备工作复杂和多面。为癌细胞设计疫苗的整个研发框架完全依赖于通知特定的相互作用和适应免疫系统这一重要方面。本综述旨在梳理以研究为基础的方法论在开发癌症治疗、预防或个性化疫苗方面的应用。该方法的重点是识别和选择作为免疫生物标志物的疫苗开发目标。此外,还讨论了个性化和精准疫苗的重要方面以及这些方法之间的细微差别。
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来源期刊
Current Genomics
Current Genomics 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
29
审稿时长
>0 weeks
期刊介绍: Current Genomics is a peer-reviewed journal that provides essential reading about the latest and most important developments in genome science and related fields of research. Systems biology, systems modeling, machine learning, network inference, bioinformatics, computational biology, epigenetics, single cell genomics, extracellular vesicles, quantitative biology, and synthetic biology for the study of evolution, development, maintenance, aging and that of human health, human diseases, clinical genomics and precision medicine are topics of particular interest. The journal covers plant genomics. The journal will not consider articles dealing with breeding and livestock. Current Genomics publishes three types of articles including: i) Research papers from internationally-recognized experts reporting on new and original data generated at the genome scale level. Position papers dealing with new or challenging methodological approaches, whether experimental or mathematical, are greatly welcome in this section. ii) Authoritative and comprehensive full-length or mini reviews from widely recognized experts, covering the latest developments in genome science and related fields of research such as systems biology, statistics and machine learning, quantitative biology, and precision medicine. Proposals for mini-hot topics (2-3 review papers) and full hot topics (6-8 review papers) guest edited by internationally-recognized experts are welcome in this section. Hot topic proposals should not contain original data and they should contain articles originating from at least 2 different countries. iii) Opinion papers from internationally recognized experts addressing contemporary questions and issues in the field of genome science and systems biology and basic and clinical research practices.
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