Bifidobacterium longum subsp. infantis YLGB‐1496—Toxicological evaluation

IF 2.7 4区医学 Q3 TOXICOLOGY

Journal of Applied Toxicology Pub Date : 2024-09-10 DOI:10.1002/jat.4688

Jian Zhao, Yueyi Guo, Qiuyue Jiang, Hanglian Lan, Wei‐Lian Hung, Barry Lynch

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Abstract

Bifidobacterium infantis YLGB‐1496, originally isolated from breast milk from a Taiwanese mother, is under study for use as a probiotic. As part of safety assessment, an Ames, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assay were conducted along with a 13‐week oral rat toxicity study. B. infantis YLGB‐1496 had no activity in any of the genotoxicity assays. Administration of the bacteria to Sprague–Dawley rats at doses ranging from 0 to 1.5 g/kg bw/day had no treatment‐related effects on any of the endpoints measured. There appear to be no concerns for translocation or pathogenicity of B. infantis YLGB‐1496 based on extensive experience with the species in general. The results of the current investigations support potential use of B. infantis YLGB‐1496 as a probiotic in infant formula.

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长双歧杆菌婴儿亚种 YLGB-1496-毒理学评价

婴儿双歧杆菌 YLGB-1496 最初是从一位台湾母亲的母乳中分离出来的，目前正在研究将其用作益生菌。作为安全性评估的一部分，进行了艾姆斯、体内小鼠微核试验和体内小鼠精母细胞染色体畸变试验，以及为期 13 周的大鼠口服毒性研究。婴儿嗜血杆菌 YLGB-1496 在任何遗传毒性试验中都没有活性。按 0 至 1.5 克/千克体重/天的剂量给 Sprague-Dawley 大鼠服用该细菌，对测量的任何终点都没有产生与治疗相关的影响。根据对婴儿肠杆菌 YLGB-1496 的广泛使用经验，似乎不存在婴儿肠杆菌 YLGB-1496 的转运或致病性问题。目前的研究结果支持将婴儿双歧杆菌 YLGB-1496 用作婴儿配方奶粉中的益生菌。

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来源期刊

Journal of Applied Toxicology 医学-毒理学

CiteScore

7.00

自引率

6.10%

发文量

145

审稿时长

1 months

期刊介绍： Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.