Association between Gastric Cancer and Vitamin D in Kashmiri Population: A 2 Year Case–Control Study at a Tertiary Care Hospital

IF 0.4 4区 医学 Q4 SURGERY
Younis Mushtaq, Shariq Rashid Masoodi, Mubashir Shah, Ajaz Qadir
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Abstract

Introduction: The association between vitamin D level and gastric cancer has not been studied in our population despite the high prevalence of vitamin D deficiency and gastric cancer. Patients and Methods: This was a 26-month case series analysis study in which 59 patients with histologically confirmed gastric cancer and age and sex-matched 60 patients with suspicion of Helicobacter Pylori infection were taken as controls to find out any association between low 25 hydroxy vitamin D level and malignancy. Results: The mean age of the cases and controls was 57 SD (standard deviation)10 and 56 SD 9 years, respectively. The mean vitamin D levels in cases and controls were 20.15 ng/ml and 32.21 ng/ml, which was statistically significant (p < 0.0001). Only 3 (5%) controls showed vitamin D deficiency (< 20 ng/ml), compared to 30 (50.84%) cases, which was statistically significant (p < 0.001). The mean vitamin D levels in well differentiated, moderately differentiated and poorly differentiated adenocarcinoma were 26.10, 23.25 and 14.88 ng/ml, respectively, which was statistically significant (p < 0.001). Stage III gastric adenocarcinoma (50.8%) was the most common, followed by stage II (42.4%), stage I (5.08%) and stage IV (1.7%); however, vitamin D levels did not statistically differ among these stages. All these patients except stage IV underwent surgery, were followed for two years, and had a survival rate of 90 percent. Conclusion: There was a positive association between vitamin D deficiency and the occurrence of gastric cancer. Vitamin D levels were significantly associated with different tumour differentiation grades but not with clinical staging.

Abstract Image

克什米尔人口中胃癌与维生素 D 的关系:一家三级医院为期两年的病例对照研究
导言:尽管维生素 D 缺乏和胃癌的发病率很高,但我国尚未研究维生素 D 水平与胃癌之间的关系。患者和方法:这是一项为期 26 个月的病例系列分析研究,以 59 名经组织学确诊的胃癌患者和 60 名年龄与性别相匹配的怀疑感染幽门螺杆菌的患者作为对照,以找出低 25 羟基维生素 D 水平与恶性肿瘤之间的关系。研究结果病例和对照组的平均年龄分别为 57 SD(标准差)10 岁和 56 SD 9 岁。病例和对照组的平均维生素 D 水平分别为 20.15 纳克/毫升和 32.21 纳克/毫升,差异有统计学意义(p < 0.0001)。只有 3 名(5%)对照组显示维生素 D 缺乏(< 20 ng/ml),而病例有 30 名(50.84%),差异有统计学意义(p < 0.001)。分化良好、中度分化和分化不良腺癌的平均维生素 D 水平分别为 26.10、23.25 和 14.88 纳克/毫升,差异有统计学意义(p <0.001)。Ⅲ期胃腺癌(50.8%)最常见,其次是Ⅱ期(42.4%)、Ⅰ期(5.08%)和Ⅳ期(1.7%);然而,维生素 D 水平在这些分期中没有统计学差异。除 IV 期外,所有这些患者都接受了手术,随访两年,存活率为 90%。结论维生素 D 缺乏与胃癌的发生呈正相关。维生素 D 水平与不同的肿瘤分化等级有明显关系,但与临床分期无关。
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来源期刊
CiteScore
0.60
自引率
25.00%
发文量
412
审稿时长
6-12 weeks
期刊介绍: The Indian Journal of Surgery is the official publication of the Association of Surgeons of India that considers for publication articles in all fields of surgery. Issues are published bimonthly in the months of February, April, June, August, October and December. The journal publishes Original article, Point of technique, Review article, Case report, Letter to editor, Teachers and surgeons from the past - A short (up to 500 words) bio sketch of a revered teacher or surgeon whom you hold in esteem and Images in surgery, surgical pathology, and surgical radiology. A trusted resource for peer-reviewed coverage of all types of surgery Provides a forum for surgeons in India and abroad to exchange ideas and advance the art of surgery The official publication of the Association of Surgeons of India 92% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again The Indian Journal of Surgery offers peer-reviewed coverage of all types of surgery. The Journal publishes Original articles, Points of technique, Review articles, Case reports, Letters, Images and brief biographies of influential teachers and surgeons. The Journal spans General Surgery, Pediatric Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Rural Surgery, Orthopedic Surgery, Urology, Surgical Oncology, Radiology, Anaesthesia, Trauma Services, Minimal Access Surgery, Endocrine Surgery, GI Surgery, ENT, Colorectal Surgery, surgical practice and research. The Journal provides a forum for surgeons from India and abroad to exchange ideas, to propagate the advancement of science and the art of surgery and to promote friendship among surgeons in India and abroad. This has been a trusted platform for surgons in communicating up-to-date scientific informeation to the community.
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