{"title":"Association between Gastric Cancer and Vitamin D in Kashmiri Population: A 2 Year Case–Control Study at a Tertiary Care Hospital","authors":"Younis Mushtaq, Shariq Rashid Masoodi, Mubashir Shah, Ajaz Qadir","doi":"10.1007/s12262-024-04152-4","DOIUrl":null,"url":null,"abstract":"<p>Introduction: The association between vitamin D level and gastric cancer has not been studied in our population despite the high prevalence of vitamin D deficiency and gastric cancer. Patients and Methods: This was a 26-month case series analysis study in which 59 patients with histologically confirmed gastric cancer and age and sex-matched 60 patients with suspicion of <i>Helicobacter Pylori </i>infection were taken as controls to find out any association between low 25 hydroxy vitamin D level and malignancy. Results: The mean age of the cases and controls was 57 SD (standard deviation)10 and 56 SD 9 years, respectively. The mean vitamin D levels in cases and controls were 20.15 ng/ml and 32.21 ng/ml, which was statistically significant (<i>p</i> < 0.0001). Only 3 (5%) controls showed vitamin D deficiency (< 20 ng/ml), compared to 30 (50.84%) cases, which was statistically significant (<i>p</i> < 0.001). The mean vitamin D levels in well differentiated, moderately differentiated and poorly differentiated adenocarcinoma were 26.10, 23.25 and 14.88 ng/ml, respectively, which was statistically significant (<i>p</i> < 0.001). Stage III gastric adenocarcinoma (50.8%) was the most common, followed by stage II (42.4%), stage I (5.08%) and stage IV (1.7%); however, vitamin D levels did not statistically differ among these stages. All these patients except stage IV underwent surgery, were followed for two years, and had a survival rate of 90 percent. Conclusion: There was a positive association between vitamin D deficiency and the occurrence of gastric cancer. Vitamin D levels were significantly associated with different tumour differentiation grades but not with clinical staging.</p>","PeriodicalId":13391,"journal":{"name":"Indian Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12262-024-04152-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: The association between vitamin D level and gastric cancer has not been studied in our population despite the high prevalence of vitamin D deficiency and gastric cancer. Patients and Methods: This was a 26-month case series analysis study in which 59 patients with histologically confirmed gastric cancer and age and sex-matched 60 patients with suspicion of Helicobacter Pylori infection were taken as controls to find out any association between low 25 hydroxy vitamin D level and malignancy. Results: The mean age of the cases and controls was 57 SD (standard deviation)10 and 56 SD 9 years, respectively. The mean vitamin D levels in cases and controls were 20.15 ng/ml and 32.21 ng/ml, which was statistically significant (p < 0.0001). Only 3 (5%) controls showed vitamin D deficiency (< 20 ng/ml), compared to 30 (50.84%) cases, which was statistically significant (p < 0.001). The mean vitamin D levels in well differentiated, moderately differentiated and poorly differentiated adenocarcinoma were 26.10, 23.25 and 14.88 ng/ml, respectively, which was statistically significant (p < 0.001). Stage III gastric adenocarcinoma (50.8%) was the most common, followed by stage II (42.4%), stage I (5.08%) and stage IV (1.7%); however, vitamin D levels did not statistically differ among these stages. All these patients except stage IV underwent surgery, were followed for two years, and had a survival rate of 90 percent. Conclusion: There was a positive association between vitamin D deficiency and the occurrence of gastric cancer. Vitamin D levels were significantly associated with different tumour differentiation grades but not with clinical staging.
期刊介绍:
The Indian Journal of Surgery is the official publication of the Association of Surgeons of India that considers for publication articles in all fields of surgery. Issues are published bimonthly in the months of February, April, June, August, October and December.
The journal publishes Original article, Point of technique, Review article, Case report, Letter to editor, Teachers and surgeons from the past - A short (up to 500 words) bio sketch of a revered teacher or surgeon whom you hold in esteem and Images in surgery, surgical pathology, and surgical radiology.
A trusted resource for peer-reviewed coverage of all types of surgery
Provides a forum for surgeons in India and abroad to exchange ideas and advance the art of surgery
The official publication of the Association of Surgeons of India
92% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again
The Indian Journal of Surgery offers peer-reviewed coverage of all types of surgery. The Journal publishes Original articles, Points of technique, Review articles, Case reports, Letters, Images and brief biographies of influential teachers and surgeons.
The Journal spans General Surgery, Pediatric Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Rural Surgery, Orthopedic Surgery, Urology, Surgical Oncology, Radiology, Anaesthesia, Trauma Services, Minimal Access Surgery, Endocrine Surgery, GI Surgery, ENT, Colorectal Surgery, surgical practice and research.
The Journal provides a forum for surgeons from India and abroad to exchange ideas, to propagate the advancement of science and the art of surgery and to promote friendship among surgeons in India and abroad. This has been a trusted platform for surgons in communicating up-to-date scientific informeation to the community.