Jaehyung Lee, Oh-Seok Kwon, Gayeon Ryu, Hangsik Shin, Hui-Nam Pak
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引用次数: 0
Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia and a major cardiovascular disease epidemic of the 21st century. Early diagnosis and intervention are crucial as AF often progresses without symptoms. This study aims to identify AF using genome-wide association studies and convolutional neural networks (CNN). Genomic data from 6,358 individuals were used to develop a CNN model, with L2 regularization applied to prevent overfitting. The L2-regularized CNN significantly outperformed the regular CNN across various p-value thresholds. For instance, at p < 0.0001, the L2-regularized CNN achieved an accuracy of 0.731 ± 0.071 compared to 0.703 ± 0.055 for the regular CNN. At p < 0.001, the L2-regularized CNN showed an accuracy of 0.630 ± 0.089, while the regular CNN had 0.577 ± 0.095. This demonstrates a notable improvement in model performance with L2 regularization. Although the regular CNN showed higher accuracy in some scenarios, such as achieving 0.984 ± 0.015 at p < 0.01 compared to 0.970 ± 0.020 for the L2-regularized CNN, the performance difference between the models decreased as the p-value threshold became more stringent. Overall, L2 regularization not only improved the model’s performance and stability but also reduced the performance gap between the models under stricter p-value conditions. These findings highlight that L2-regularized CNNs can significantly enhance performance in genomic studies, offering a more effective alternative to traditional polygenic risk score methods for AF identification study.
期刊介绍:
ournal of Electrical Engineering and Technology (JEET), which is the official publication of the Korean Institute of Electrical Engineers (KIEE) being published bimonthly, released the first issue in March 2006.The journal is open to submission from scholars and experts in the wide areas of electrical engineering technologies.
The scope of the journal includes all issues in the field of Electrical Engineering and Technology. Included are techniques for electrical power engineering, electrical machinery and energy conversion systems, electrophysics and applications, information and controls.