Synthesis and biomedical potential of silk fiber/methylcellulose composite containing copper and zinc co-substituted hydroxyapatite for bone tissue engineering applications

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-09-03 DOI:10.1016/j.molstruc.2024.139922

引用次数: 0

Abstract

The primary feature of biomaterials is to aid in the regeneration of damaged tissues and organs. To attain a biomaterial, we fabricated a double mineral (copper and zinc) substituted hydroxyapatite/silk fiber/methylcellulose (CZ-HAP/SF/MC) nanocomposite by the E-Spin method. The as-developed CZ-HAP/SF/MC nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and moreover, the fabricated nanocomposites were used to investigate morphological changes, porosity, swelling test, mechanical strength, antibacterial activity and apatite growth. In addition, antimicrobial studies demonstrated that CZ-HAP/SF/MC nanocomposite exhibited excellent antimicrobial activity against S. aureus, E. coli and C. albicans and, the resultant nanocomposite revealed that the CZ-HAP/SF/MC nanocomposite will be an effective implant material for better cell growth in BTE applications.

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含铜锌共取代羟基磷灰石的丝纤维/甲基纤维素复合材料的合成及其在骨组织工程应用中的生物医学潜力

生物材料的主要功能是帮助受损组织和器官再生。为了实现这种生物材料，我们采用 E-Spin 法制备了双矿物（铜和锌）取代羟基磷灰石/蚕丝纤维/甲基纤维素（CZ-HAP/SF/MC）纳米复合材料。傅立叶变换红外光谱（FT-IR）和 X 射线衍射（XRD）对所制备的 CZ-HAP/SF/MC 纳米复合材料进行了表征，此外，还对所制备的纳米复合材料的形态变化、孔隙率、膨胀试验、机械强度、抗菌活性和磷灰石生长进行了研究。此外，抗菌研究表明，CZ-HAP/SF/MC 纳米复合材料对金黄色葡萄球菌、大肠杆菌和白僵菌具有极佳的抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.

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