Application and prospect of Cu-based metal-organic frameworks in tumor therapy

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-09-11 DOI:10.1016/j.molstruc.2024.139984

引用次数: 0

Abstract

Cancer has been one of the significant threats to human well-being in recent decades. Metal-organic frameworks (MOFs) are three-dimensional structural materials formulated of metal ions or metal clusters combined with polydentate organic moieties. They have controllable morphology, customizable diameter, adjustable porousness, elevated specific surface area, easy functionalization, and good biocompatibility. Many researchers have used MOFs' excellent and unique properties to design nano-platforms conducive to treating tumors. The present review summarizes the recent progress of copper-based MOF nanoplatforms for tumor treatment through different treatment stratgies, including chemotherapy, photothermal therapy, sonodynamic therapy and combined treatment methods and discusses the physiological mechanism and unique biological effects of copper(II)-based MOFs. Finally, we outlooked the current status of Cu-based MOFs in tumor therapy and prospect the changllent and potential development in anti-tumor in future.

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铜基金属有机框架在肿瘤治疗中的应用和前景

近几十年来，癌症一直是人类健康的重大威胁之一。金属有机框架（MOFs）是由金属离子或金属团簇与多齿有机分子结合而成的三维结构材料。它们具有可控的形态、可定制的直径、可调节的孔隙度、较高的比表面积、易于功能化以及良好的生物相容性。许多研究人员利用 MOFs 的优异独特性能设计出了有利于治疗肿瘤的纳米平台。本综述总结了近年来铜基 MOF 纳米平台通过化疗、光热治疗、声动力治疗和联合治疗等不同治疗手段治疗肿瘤的进展，并探讨了铜（II）基 MOFs 的生理机制和独特的生物效应。最后，展望了铜基 MOFs 在肿瘤治疗中的应用现状，并展望了其在未来抗肿瘤领域的变化和发展潜力。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.