Traditional Chinese Medicine in the treatment of chronic atrophic gastritis, precancerous lesions and gastric cancer

IF 4.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of ethnopharmacology Pub Date : 2024-09-10 DOI:10.1016/j.jep.2024.118812

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引用次数: 0

Abstract

Ethnopharmacological relevance

Chronic atrophic gastritis (CAG), precancerous lesions of gastric cancer (PLGC), and gastric cancer (GC), seriously threaten human health. Traditional Chinese medicine (TCM) has been employed in the treatment of chronic diseases for a long time and has shown remarkable efficacy.

Aim of the study

Recently, there has been an increasing use of TCM in treating CAG, PLGC, and GC. The objective of this study is to compile a comprehensive overview of the existing research on the effects and molecular mechanisms of TCM, including formulas, single herbs, and active components.

Materials and methods

To obtain a comprehensive understanding of traditional use of TCM in treating these diseases, we reviewed ancient books and Chinese literature. In addition, keywords such as “TCM”, “CAG”, “PLGC”, “GC”, and “active ingredients” were used to collect modern research on TCM published in databases such as CNKI, Web of Science, and Pubmed up to April 2024. All collected information was then summarized and analyzed.

Results

This study analyzed 174 articles, which covered the research progress of 20 TCM formulas, 14 single herbs, and 50 active ingredients in treating CAG, PLGC, and GC. Sources, effects, and molecular mechanisms of the TCM were summarized.

Conclusions

This article reviews the progress of TCM in the management of CAG, PLGC, and GC, which will provide a foundation for the clinical application and further development of TCM.

Abstract Image

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中药治疗慢性萎缩性胃炎、癌前病变和胃癌

民族药学意义慢性萎缩性胃炎（CAG）、胃癌癌前病变（PLGC）和胃癌（GC）严重威胁人类健康。长期以来，中医药一直被用于治疗慢性疾病，且疗效显著。本研究的目的是全面梳理现有关于中药作用和分子机制的研究，包括方剂、单味药材和有效成分。材料和方法为了全面了解传统上使用中药治疗这些疾病的情况，我们查阅了古籍和中文文献。此外，我们还使用 "TCM"、"CAG"、"PLGC"、"GC "和 "有效成分 "等关键词收集了截至 2024 年 4 月在 CNKI、Web of Science 和 Pubmed 等数据库中发表的有关中药的现代研究。结果本研究分析了 174 篇文章，涉及 20 个中药方剂、14 种单味药材和 50 种有效成分在治疗 CAG、PLGC 和 GC 方面的研究进展。结论本文回顾了中医药在治疗 CAG、PLGC 和 GC 方面的研究进展，为中医药的临床应用和进一步发展奠定了基础。

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来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.