From backstage to the spotlight: γδT cells in cancer

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-12 DOI:10.1016/j.ccell.2024.08.017

Robert Wiesheu, Seth B. Coffelt

引用次数: 0

Abstract

γδT cells represent a group of immune cells that are understudied but whose utility has been recognized for cancer immunotherapy purposes. Recent studies have highlighted a critical role for these cells in tumor initiation, growth, and metastasis and revealed an increasingly complex biology of γδT cell subsets that is context and tissue specific. We discuss here how γδT cell subsets are regulated, their interaction with cancer and other immune cells, and the implications from these latest discoveries for people with cancer.

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从后台到聚光灯下：癌症中的γδT 细胞

γδT细胞是一组研究不足的免疫细胞，但其在癌症免疫疗法中的作用已得到认可。最近的研究强调了这些细胞在肿瘤发生、生长和转移中的关键作用，并揭示了γδT 细胞亚群日益复杂的生物学特性，这种特性具有环境和组织特异性。我们在此讨论γδT 细胞亚群是如何被调控的、它们与癌症和其他免疫细胞的相互作用，以及这些最新发现对癌症患者的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.