Ovarian cancer metastasis: Looking beyond the surface

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-12 DOI:10.1016/j.ccell.2024.08.016

Emine Bayraktar, Sisy Chen, Sara Corvigno, Jinsong Liu, Anil K. Sood

引用次数: 0

Abstract

Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC). Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including peritoneal, hematogenous, lymphatic, and nerve-related. Understanding the underlying mechanisms is necessary to improve treatment strategies for this challenging disease.

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卵巢癌转移：透过表面看本质

过去，人们认为卵巢癌（OC）是通过表面到表面的扩散转移的，但最近的发展让人们对转移扩散的途径有了新的认识。鉴于卵巢癌的组织学和分子异质性，我们将重点关注高级别浆液性癌（HGSC）。在此，我们将对支持各种转移途径（包括腹膜转移、血行转移、淋巴转移和神经相关转移）的证据进行批判性和更全面的审视。要改善这种具有挑战性疾病的治疗策略，就必须了解其根本机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.