The association between slow-wave sleep and choroid plexus calcifications in older adults. Results from the sleep disorders substudy of the Atahualpa Project cohort.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
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Abstract

Objective

It has been suggested that choroid plexus calcifications (CPC) may be associated with glymphatic system dysfunction and with disturbed slow-wave (N3) sleep. If this is the case, volumetric analysis of CPC could be used to estimate the functional ability of the glymphatic system. However, data on this association is limited. This study aims to assess the association between percentages of N3 sleep – used as a putative marker of glymphatic system activity – and the volume of CPC in older adults.

Patients and methods

Community-dwelling individuals aged ≥60 years enrolled in the Atahualpa Project Cohort received head CTs (for automated determinations of CPC volume) and a single-night polysomnography (PSG) for quantification of N3 sleep percentages. Multivariate linear regression and non-parametric models were fitted to assess the association between these variables.

Results

A total of 125 older adults (median age: 65 years; 32 % males) were included. The mean percentage of N3 sleep was 12.4±9.1 %, and the mean volume of CPC was 655±345.3 µL. Non-parametric locally weighted scatterplot smoothing showed that the volume of CPC increased as the percentage of N3 sleep increased, but only when N3 sleep is reduced (up to 12 % of total sleep time). The significance disappeared when PSG parameters were included in the model as well as in participants with normal N3 sleep percentages.

Conclusions

Study results suggest that in the presence of severe reductions in N3 sleep, increased CPC volume may be a manifestation of choroid plexus compensation or adaptation, and not necessarily dysfunction.

老年人慢波睡眠与脉络丛钙化之间的关系。阿塔瓦尔帕项目队列睡眠障碍子研究结果。
目的 有人认为脉络丛钙化(CPC)可能与甘液系统功能障碍和慢波(N3)睡眠紊乱有关。如果情况属实,则可利用脉络丛钙化的容积分析来估测甘液系统的功能能力。然而,有关这种关联的数据还很有限。本研究旨在评估老年人N3睡眠百分比(N3睡眠被认为是甘液系统活动的标志)与CPC体积之间的关联。患者和方法Atahualpa项目队列中年龄≥60岁的社区居民接受头部CT检查(用于自动测定CPC体积)和单晚多导睡眠图(PSG)检查,以量化N3睡眠百分比。多变量线性回归和非参数模型用于评估这些变量之间的关联。N3 睡眠的平均比例为 12.4±9.1%,CPC 的平均体积为 655±345.3 µL。非参数局部加权散点图平滑显示,随着 N3 睡眠百分比的增加,CPC 的体积也在增加,但只有当 N3 睡眠减少时(最多占总睡眠时间的 12%)才会增加。结论研究结果表明,在 N3 睡眠严重减少的情况下,CPC 体积增加可能是脉络丛代偿或适应的一种表现,而不一定是功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Neurology and Neurosurgery
Clinical Neurology and Neurosurgery 医学-临床神经学
CiteScore
3.70
自引率
5.30%
发文量
358
审稿时长
46 days
期刊介绍: Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.
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