Associations of Diabetes and Prediabetes With Mortality and Life Expectancy in China: A National Study

IF 14.8 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes Care Pub Date : 2024-09-10 DOI:10.2337/dca24-0012
Yunli Tian, Zixin Qiu, Feixue Wang, Shan Deng, Yue Wang, Zi Wang, Peng Yin, Yong Huo, Maigeng Zhou, Gang Liu, Kai Huang
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Abstract

OBJECTIVE To investigate the excess mortality and life-years lost associated with diabetes and prediabetes in China. RESEARCH DESIGN AND METHODS This national cohort study enrolled 135,405 participants aged 18 years or older from the general population in China. Cox proportional hazards regression models were used to estimate adjusted mortality rate ratio (RR). The life table method was used to estimate life expectancy. RESULTS Among the 135,405 participants, 10.5% had diabetes and 36.2% had prediabetes in 2013. During a median follow-up of 6 years, 5517 deaths were recorded, including 1428 and 2300 deaths among people with diabetes and prediabetes, respectively. Diabetes and prediabetes were significantly associated with increased risk of all-cause (diabetes: RR, 1.61 [95% CI 1.49, 1.73]; prediabetes: RR, 1.08 [95% CI 1.01, 1.15]), and cardiovascular disease (diabetes: RR, 1.59 [95% CI 1.41, 1.78]; prediabetes: RR, 1.10 [95% CI 1.00, 1.21]) mortality. Additionally, diabetes was significantly associated with increased risks of death resulting from cancer, respiratory disease, liver disease, and diabetic ketoacidosis or coma. Compared with participants with normoglycemia, life expectancy of those with diabetes and prediabetes was shorter, on average, by 4.2 and 0.7 years at age 40 years, respectively. The magnitude of the associations of diabetes and prediabetes with all-cause and cardiovascular disease mortality varied by age and residence. CONCLUSIONS In this national study, diabetes and prediabetes were significantly associated with reduced life expectancy and increased all-cause and cause-specific mortality risks. The disparities in excess mortality associated with diabetes and prediabetes between different ages and residences have implications for diabetes and prediabetes prevention and treatment programs.
中国糖尿病和糖尿病前期与死亡率和预期寿命的关系:一项全国性研究
目的 调查中国与糖尿病和糖尿病前期相关的超额死亡率和寿命损失。研究设计与方法 这项全国性队列研究从中国普通人群中招募了 135,405 名 18 岁或以上的参与者。采用 Cox 比例危险回归模型估算调整后的死亡率比值(RR)。采用生命表法估算预期寿命。结果 在2013年的135405名参与者中,10.5%患有糖尿病,36.2%患有糖尿病前期。在中位 6 年的随访期间,共记录了 5517 例死亡,其中糖尿病患者和糖尿病前期患者的死亡人数分别为 1428 例和 2300 例。RR,1.61 [95% CI 1.49,1.73];糖尿病前期:RR, 1.08 [95% CI 1.01, 1.15])和心血管疾病(糖尿病:RR, 1.59 [95% CI 1.49, 1.73];糖尿病前期:RR, 1.08 [95% CI 1.01, 1.15RR,1.59 [95% CI 1.41,1.78];糖尿病前期:RR,1.10 [95% CI 1.01,1.15]:RR,1.10 [95% CI 1.00,1.21])死亡率。此外,糖尿病还与癌症、呼吸系统疾病、肝脏疾病、糖尿病酮症酸中毒或昏迷导致的死亡风险增加有显著关联。与血糖正常者相比,糖尿病和糖尿病前期患者在 40 岁时的预期寿命平均分别缩短了 4.2 年和 0.7 年。糖尿病和糖尿病前期与全因死亡率和心血管疾病死亡率的关联程度因年龄和居住地而异。结论 在这项全国性研究中,糖尿病和糖尿病前期与预期寿命缩短、全因和特定原因死亡风险增加密切相关。与糖尿病和糖尿病前期相关的超额死亡率在不同年龄和居住地之间存在差异,这对糖尿病和糖尿病前期预防和治疗计划具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetes Care
Diabetes Care 医学-内分泌学与代谢
CiteScore
27.80
自引率
4.90%
发文量
449
审稿时长
1 months
期刊介绍: The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.
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