Belantamab mafodotin, pomalidomide, and dexamethasone for triple class exposed/refractory relapsed multiple myeloma: a subgroup analysis of the ALGONQUIN trial

IF 12.9 1区 医学 Q1 HEMATOLOGY
Arleigh McCurdy, Donna Reece, Martha L. Louzada, Darrell White, Stephen Parkin, Michael P. Chu, Rami Kotb, Hira Mian, Ibraheem Othman, Jiandong Su, Aniba Khan, Engin Gul, Suzanne Trudel
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Abstract

Given the early use of triplet and quadruplet regimens, most patients with multiple myeloma (MM) will be exposed and/or refractory to PIs, IMiDs, and anti-CD38 mAbs after first- or second-line treatment. Effective treatment for this group of triple class exposed/refractory (TCE/R) patients is crucial. Here we present a post-hoc subgroup analysis of TCE/R patients treated on the ALGONQUIN study of belantamab mafodotin plus pomalidomide-dexamethasone (belamaf-Pd) for relapsed MM. Of the 99 patients treated on the ALGONQUIN study, 69 were TCE and 56 were TCR and were included in this analysis. Patients had a median of three prior lines of therapy. The ORR was 86.4% in TCE patients and 84.9% in TCR patients, with ≥ very good partial response rates of 64% and 68% respectively. The median progression free survival was 18.3 months in TCE patients and 19.6 months in TCR patients, with overall survival not yet reached and 34.4 months, respectively for TCE and TCR patients. No new safety signals were identified. The most common Grade ≥ 3 AEs were keratopathy (48%), decreased visual acuity (42%), neutropenia (36%), thrombocytopenia (27%), and infection (25%). In this subgroup analysis of the ALGONQUIN study, patients with TCE/TCR disease treated with belamaf-Pd achieved high clinical response rates with durable remissions, comparable to other novel therapeutics in this space.

Abstract Image

贝仑单抗马福多汀、泊马度胺和地塞米松治疗三类暴露/难治性复发性多发性骨髓瘤:ALGONQUIN试验的亚组分析
鉴于三联疗法和四联疗法的早期使用,大多数多发性骨髓瘤(MM)患者在经过一线或二线治疗后,会对PIs、IMiDs和抗CD38 mAbs产生暴露和/或难治性。对这部分三类药物暴露/难治(TCE/R)患者进行有效治疗至关重要。在此,我们对接受贝仑单抗-马福多汀+泊马度胺-地塞米松(belamaf-Pd)治疗复发性 MM 的 ALGONQUIN 研究的 TCE/R 患者进行了事后亚组分析。在接受ALGONQUIN研究治疗的99例患者中,69例为TCE患者,56例为TCR患者,这些患者都纳入了本次分析。患者之前接受过中位数三线治疗。TCE患者的ORR为86.4%,TCR患者的ORR为84.9%,≥非常好的部分反应率分别为64%和68%。TCE患者的中位无进展生存期为18.3个月,TCR患者为19.6个月,总生存期尚未达到,TCE和TCR患者分别为34.4个月。未发现新的安全性信号。最常见的≥3级AE为角膜病变(48%)、视力下降(42%)、中性粒细胞减少(36%)、血小板减少(27%)和感染(25%)。在ALGONQUIN研究的这项亚组分析中,接受belamaf-Pd治疗的TCE/TCR患者获得了较高的临床应答率和持久缓解,与该领域的其他新型疗法不相上下。
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来源期刊
CiteScore
16.70
自引率
2.30%
发文量
153
审稿时长
>12 weeks
期刊介绍: Blood Cancer Journal is dedicated to publishing high-quality articles related to hematologic malignancies and related disorders. The journal welcomes submissions of original research, reviews, guidelines, and letters that are deemed to have a significant impact in the field. While the journal covers a wide range of topics, it particularly focuses on areas such as: Preclinical studies of new compounds, especially those that provide mechanistic insights Clinical trials and observations Reviews related to new drugs and current management of hematologic malignancies Novel observations related to new mutations, molecular pathways, and tumor genomics Blood Cancer Journal offers a forum for expedited publication of novel observations regarding new mutations or altered pathways.
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