In vivo dosimetry with an inorganic scintillation detector during multi-channel vaginal cylinder pulsed dose-rate brachytherapy: Dosimetry for pulsed dose-rate brachytherapy

IF 3.4 Q2 ONCOLOGY
Peter D. Georgi , Søren K. Nielsen , Anders T. Hansen , Harald Spejlborg , Susanne Rylander , Jacob Lindegaard , Simon Buus , Christian Wulff , Primoz Petric , Kari Tanderup , Jacob G. Johansen
{"title":"In vivo dosimetry with an inorganic scintillation detector during multi-channel vaginal cylinder pulsed dose-rate brachytherapy: Dosimetry for pulsed dose-rate brachytherapy","authors":"Peter D. Georgi ,&nbsp;Søren K. Nielsen ,&nbsp;Anders T. Hansen ,&nbsp;Harald Spejlborg ,&nbsp;Susanne Rylander ,&nbsp;Jacob Lindegaard ,&nbsp;Simon Buus ,&nbsp;Christian Wulff ,&nbsp;Primoz Petric ,&nbsp;Kari Tanderup ,&nbsp;Jacob G. Johansen","doi":"10.1016/j.phro.2024.100638","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><p>In vivo dosimetry is not standard in brachytherapy and some errors go undetected. The aim of this study was to evaluate the accuracy of multi-channel vaginal cylinder pulsed dose-rate brachytherapy using in vivo dosimetry.</p></div><div><h3>Materials and methods</h3><p>In vivo dosimetry data was collected during the years 2019–2022 for 22 patients (32 fractions) receiving multi-channel cylinder pulsed dose-rate brachytherapy. An inorganic scintillation detector was inserted in a cylinder channel. Each fraction was analysed as independent data sets. In vivo dosimetry-based source-tracking was used to determine the relative source-to-detector position. Measured dose was compared to planned and re-calculated source-tracking based doses. Assuming no change in organ and applicator geometry throughout treatment, the planned and source-tracking based dose distributions were compared in select volumes via γ-index analysis and dose-volume-histograms.</p></div><div><h3>Results</h3><p>The mean ± SD planned vs. measured dose deviations in the first pulse were 0.8 <span><math><mrow><mo>±</mo></mrow></math></span> 5.9 %. In 31/32 fractions the deviation was within the combined in vivo dosimetry uncertainty (averaging 9.7 %, <em>k =</em> 2) and planning dose calculation uncertainty (1.6 %, <em>k =</em> 2). The dwell-position offsets were &lt; 2 mm for 88 % of channels, with the largest being 5.1 mm (4.0 mm uncertainty, <em>k =</em> 2). 3 %/2 mm γ pass-rates averaged 97.0 % (clinical target volume (CTV)), 100.0 % (rectum), 99.9 % (bladder). The mean ± SD deviation was −1.<span><math><mrow><mn>1</mn></mrow></math></span> ± 2.9 % for CTV D98, and −0.2 ± 0.9 % and −1.2 ± 2.5 %, for bladder and rectum D2cm<sup>3</sup> respectively, indicating good agreement between intended and delivered dose.</p></div><div><h3>Conclusions</h3><p>In vivo dosimetry verified accurate and stable dose delivery in multi-channel vaginal cylinder based pulsed dose-rate brachytherapy.</p></div>","PeriodicalId":36850,"journal":{"name":"Physics and Imaging in Radiation Oncology","volume":"32 ","pages":"Article 100638"},"PeriodicalIF":3.4000,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405631624001088/pdfft?md5=e582505d93f2167330a052ddaf354c3b&pid=1-s2.0-S2405631624001088-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics and Imaging in Radiation Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405631624001088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and purpose

In vivo dosimetry is not standard in brachytherapy and some errors go undetected. The aim of this study was to evaluate the accuracy of multi-channel vaginal cylinder pulsed dose-rate brachytherapy using in vivo dosimetry.

Materials and methods

In vivo dosimetry data was collected during the years 2019–2022 for 22 patients (32 fractions) receiving multi-channel cylinder pulsed dose-rate brachytherapy. An inorganic scintillation detector was inserted in a cylinder channel. Each fraction was analysed as independent data sets. In vivo dosimetry-based source-tracking was used to determine the relative source-to-detector position. Measured dose was compared to planned and re-calculated source-tracking based doses. Assuming no change in organ and applicator geometry throughout treatment, the planned and source-tracking based dose distributions were compared in select volumes via γ-index analysis and dose-volume-histograms.

Results

The mean ± SD planned vs. measured dose deviations in the first pulse were 0.8 ± 5.9 %. In 31/32 fractions the deviation was within the combined in vivo dosimetry uncertainty (averaging 9.7 %, k = 2) and planning dose calculation uncertainty (1.6 %, k = 2). The dwell-position offsets were < 2 mm for 88 % of channels, with the largest being 5.1 mm (4.0 mm uncertainty, k = 2). 3 %/2 mm γ pass-rates averaged 97.0 % (clinical target volume (CTV)), 100.0 % (rectum), 99.9 % (bladder). The mean ± SD deviation was −1.1 ± 2.9 % for CTV D98, and −0.2 ± 0.9 % and −1.2 ± 2.5 %, for bladder and rectum D2cm3 respectively, indicating good agreement between intended and delivered dose.

Conclusions

In vivo dosimetry verified accurate and stable dose delivery in multi-channel vaginal cylinder based pulsed dose-rate brachytherapy.

在多通道阴道圆筒脉冲剂量率近距离放射治疗中使用无机闪烁探测器进行体内剂量测定:脉冲剂量率近距离放射治疗的剂量测定
背景和目的体内剂量测定并非近距离放射治疗的标准,有些误差会被忽视。本研究旨在利用体内剂量测定评估多通道阴道圆筒脉冲剂量率近距离放射治疗的准确性。材料和方法在2019-2022年间收集了22名接受多通道圆筒脉冲剂量率近距离放射治疗的患者(32个分次)的体内剂量测定数据。无机闪烁探测器安装在圆柱体通道中。每个部分都作为独立的数据集进行分析。使用基于体内剂量测定的放射源跟踪来确定放射源到探测器的相对位置。将测量到的剂量与计划剂量和基于源追踪重新计算的剂量进行比较。假设在整个治疗过程中器官和涂抹器的几何形状没有变化,则通过γ指数分析和剂量-体积-柱状图对选定体积中的计划剂量和基于源追踪的剂量分布进行比较。在 31/32 个馏分中,偏差在体内剂量测定不确定性(平均 9.7%,k = 2)和计划剂量计算不确定性(1.6%,k = 2)的综合范围内。88%的通道的停留位置偏差为 2 毫米,最大为 5.1 毫米(不确定性为 4.0 毫米,k = 2)。3 %/2 mm γ 通过率平均为 97.0 %(临床目标容积 (CTV))、100.0 %(直肠)和 99.9 %(膀胱)。CTV D98 的平均偏差(± SD)为-1.1 ± 2.9 %,膀胱和直肠 D2cm3 的平均偏差(± SD)分别为-0.2 ± 0.9 %和-1.2 ± 2.5 %,这表明预期剂量与输送剂量之间存在良好的一致性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信