{"title":"Rice E3 ubiquitin ligases: From key modulators of host immunity to potential breeding application.","authors":"Yuqing Yan, Hui Wang, Yan Bi, Fengming Song","doi":"10.1016/j.xplc.2024.101128","DOIUrl":null,"url":null,"abstract":"<p><p>To combat pathogen attacks, plants have developed a highly advanced immune system, which requires tight regulation to initiate robust defense responses while preventing autoimmunity simultaneously. The ubiquitin-proteasome system (UPS), responsible for degrading excess or misfolded proteins, exerts vital roles in ensuring strong and effective immune responses. E3 ligases, as key UPS components, have been extensively documented in rice immunity through modulating the ubiquitination and degradation of downstream substrates involved in various immune signaling pathways. Here, we summarize the crucial roles of rice E3 ligases in both pathogen/microbe/damage-associated molecular pattern-triggered immunity and effector-triggered immunity, highlight the molecular mechanisms of E3 ligases in rice immune signaling, and emphasize the functions of E3 ligases as targets of pathogen effectors for pathogenesis. We also discuss potential strategies for application of the immunity-associated E3 ligases in breeding disease-resistant rice varieties without growth penalty. This review thus provides comprehensive and updated understanding on the sophisticated and interconnected regulatory functions of E3 ligases in rice immunity and its balancing with growth and development.</p>","PeriodicalId":52373,"journal":{"name":"Plant Communications","volume":null,"pages":null},"PeriodicalIF":9.4000,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plant Communications","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.xplc.2024.101128","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
To combat pathogen attacks, plants have developed a highly advanced immune system, which requires tight regulation to initiate robust defense responses while preventing autoimmunity simultaneously. The ubiquitin-proteasome system (UPS), responsible for degrading excess or misfolded proteins, exerts vital roles in ensuring strong and effective immune responses. E3 ligases, as key UPS components, have been extensively documented in rice immunity through modulating the ubiquitination and degradation of downstream substrates involved in various immune signaling pathways. Here, we summarize the crucial roles of rice E3 ligases in both pathogen/microbe/damage-associated molecular pattern-triggered immunity and effector-triggered immunity, highlight the molecular mechanisms of E3 ligases in rice immune signaling, and emphasize the functions of E3 ligases as targets of pathogen effectors for pathogenesis. We also discuss potential strategies for application of the immunity-associated E3 ligases in breeding disease-resistant rice varieties without growth penalty. This review thus provides comprehensive and updated understanding on the sophisticated and interconnected regulatory functions of E3 ligases in rice immunity and its balancing with growth and development.
期刊介绍:
Plant Communications is an open access publishing platform that supports the global plant science community. It publishes original research, review articles, technical advances, and research resources in various areas of plant sciences. The scope of topics includes evolution, ecology, physiology, biochemistry, development, reproduction, metabolism, molecular and cellular biology, genetics, genomics, environmental interactions, biotechnology, breeding of higher and lower plants, and their interactions with other organisms. The goal of Plant Communications is to provide a high-quality platform for the dissemination of plant science research.