Prevalence, Awareness, and Factors Associated with Hypertension Among People Living with HIV in Eastern Uganda. A Multicentre Cross-Sectional Study.

IF 1.5 Q4 INFECTIOUS DISEASES

HIV AIDS-Research and Palliative Care Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI:10.2147/HIV.S477809

Andrew Marvin Kanyike, Ashley Winfred Nakawuki, Gabriel Madut Akech, Raymond Bernard Kihumuro, Timothy Mwanje Kintu, Racheal Nalunkuma, Rachael Mukisa Nakandi, Joshua Mugabi, Nicholas Twijukye, Denis Bwayo, Richard Katuramu

{"title":"Prevalence, Awareness, and Factors Associated with Hypertension Among People Living with HIV in Eastern Uganda. A Multicentre Cross-Sectional Study.","authors":"Andrew Marvin Kanyike, Ashley Winfred Nakawuki, Gabriel Madut Akech, Raymond Bernard Kihumuro, Timothy Mwanje Kintu, Racheal Nalunkuma, Rachael Mukisa Nakandi, Joshua Mugabi, Nicholas Twijukye, Denis Bwayo, Richard Katuramu","doi":"10.2147/HIV.S477809","DOIUrl":null,"url":null,"abstract":"Introduction: Despite advancements in Antiretroviral Therapy (ART), people living with HIV (PLHIV) face increasing risks of HTN, leading to significant morbidity and premature mortality, undermining the hard-earned gains of fighting HIV. The prevalence of hypertension among HIV patients and associated risk factors has not been extensively studied in the rural parts of Uganda.Objective: We assessed the prevalence, awareness, and factors associated with hypertension among PLHIV at two health facilities in Eastern Uganda.Methods: A cross-sectional study was conducted at Mbale Regional Referral Hospital and Bugobero Health Center IV HIV clinics from May to July 2023. We recruited patients with HIV above the age of 18 years and willing to consent. Participants were interviewed using a structured questionnaire adapted from the WHO STEPwise approach to noncommunicable disease risk factor surveillance (STEPS) and the AIDS Clinical Trials Group. Anthropometric measurements and blood pressure were taken. Bivariate and multivariable logistic regression were performed. A P value <0.2 in the bivariate analysis was transferred to the multivariable logistic regression model. A P value < 0.05 was statistically significant.Results: The study surveyed 400 PLHIV with a mean age of 46.5 (SD: 12.4) years; most were female (n=261, 65.3%). Hypertension prevalence was at 37.5%, with 20.5% in stage 2 and 68% ((n=102) of hypertensive participants were unaware. Hypertension was associated with age ≥50 years (aOR: 2.11, 95% CI: 1.33-3.37, p = 0.002), a suppressed viral load (aOR: 3.71, 95% CI: 1.02-5.13, p = 0.046) and BMI ≥25 Kg/m2 (aOR: 1.64, 95% CI: 1.01-2.66, p = 0.044).Conclusion: Hypertension is a significant burden among PLHIV in Eastern Uganda, influenced by HIV and lifestyle-related risk factors. Improved screening and diagnosis are needed with close monitoring for patients with viral load suppression due to the possible negative effects of ART on blood pressure.","PeriodicalId":46555,"journal":{"name":"HIV AIDS-Research and Palliative Care","volume":"16 ","pages":"325-335"},"PeriodicalIF":1.5000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378986/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"HIV AIDS-Research and Palliative Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/HIV.S477809","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Despite advancements in Antiretroviral Therapy (ART), people living with HIV (PLHIV) face increasing risks of HTN, leading to significant morbidity and premature mortality, undermining the hard-earned gains of fighting HIV. The prevalence of hypertension among HIV patients and associated risk factors has not been extensively studied in the rural parts of Uganda.

Objective: We assessed the prevalence, awareness, and factors associated with hypertension among PLHIV at two health facilities in Eastern Uganda.

Methods: A cross-sectional study was conducted at Mbale Regional Referral Hospital and Bugobero Health Center IV HIV clinics from May to July 2023. We recruited patients with HIV above the age of 18 years and willing to consent. Participants were interviewed using a structured questionnaire adapted from the WHO STEPwise approach to noncommunicable disease risk factor surveillance (STEPS) and the AIDS Clinical Trials Group. Anthropometric measurements and blood pressure were taken. Bivariate and multivariable logistic regression were performed. A P value <0.2 in the bivariate analysis was transferred to the multivariable logistic regression model. A P value < 0.05 was statistically significant.

Results: The study surveyed 400 PLHIV with a mean age of 46.5 (SD: 12.4) years; most were female (n=261, 65.3%). Hypertension prevalence was at 37.5%, with 20.5% in stage 2 and 68% ((n=102) of hypertensive participants were unaware. Hypertension was associated with age ≥50 years (aOR: 2.11, 95% CI: 1.33-3.37, p = 0.002), a suppressed viral load (aOR: 3.71, 95% CI: 1.02-5.13, p = 0.046) and BMI ≥25 Kg/m² (aOR: 1.64, 95% CI: 1.01-2.66, p = 0.044).

Conclusion: Hypertension is a significant burden among PLHIV in Eastern Uganda, influenced by HIV and lifestyle-related risk factors. Improved screening and diagnosis are needed with close monitoring for patients with viral load suppression due to the possible negative effects of ART on blood pressure.

查看原文本刊更多论文

乌干达东部艾滋病病毒感染者中高血压的患病率、认知度及相关因素。一项多中心横断面研究。

导言：尽管抗逆转录病毒疗法（ART）取得了进展，但艾滋病病毒感染者（PLHIV）仍面临着越来越高的高血压风险，导致严重的发病率和过早死亡，破坏了来之不易的艾滋病防治成果。在乌干达农村地区，尚未对艾滋病患者的高血压患病率及相关风险因素进行广泛研究：我们在乌干达东部的两家医疗机构评估了艾滋病毒感染者中高血压的患病率、认知度和相关因素：这项横断面研究于 2023 年 5 月至 7 月在姆巴莱地区转诊医院和布格贝罗健康中心第四艾滋病诊所进行。我们招募了年龄在 18 岁以上且自愿同意的艾滋病病毒感染者。我们使用结构化问卷对参与者进行了访谈，该问卷改编自世界卫生组织（WHO）的非传染性疾病风险因素监测 STEPwise 方法（STEPS）和艾滋病临床试验小组（AIDS Clinical Trials Group）。此外，还测量了人体测量数据和血压。进行了双变量和多变量逻辑回归。P值小于0.05为具有统计学意义：研究调查了 400 名艾滋病毒感染者，他们的平均年龄为 46.5 岁（标准差：12.4 岁）；大多数为女性（n=261，65.3%）。高血压患病率为 37.5%，其中 20.5% 处于第二阶段，68%（102 人）的高血压患者不自知。高血压与年龄≥50 岁（aOR：2.11，95% CI：1.33-3.37，p = 0.002）、病毒载量抑制（aOR：3.71，95% CI：1.02-5.13，p = 0.046）和体重指数≥25 Kg/m2 （aOR：1.64，95% CI：1.01-2.66，p = 0.044）有关：高血压是乌干达东部艾滋病毒感染者中的一个重大负担，受到艾滋病毒和生活方式相关风险因素的影响。由于抗逆转录病毒疗法可能会对血压产生负面影响，因此需要加强筛查和诊断，并对病毒载量得到抑制的患者进行密切监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

HIV AIDS-Research and Palliative Care INFECTIOUS DISEASES-

CiteScore

3.00

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.